Search Results

Overview

Uniprot IDQ9ULM3
Protein NameYEATS domain-containing protein 2
Gene NameYEATS2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
649 SAKVQPSKVVGVPVG
685 KASSSVSKAVGPKQV
766 LYLTTNSKNPSGKGK

Function

Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431)

Protein Sequence

10 MSGIKRTIKE 20 TDPDYEDVSV 30 ALPNKRHKAI 40 ENSARDAAVQ 50 KIETIIKEQF 60 ALEMKNKEHE 70 IEVIDQRLIE 80 ARRMMDKLRA 90 CIVANYYASA 100 GLLKVSEGSK 110 TCDTMVFNHP 120 AIKKFLESPS 130 RSSSPANQRA 140 ETPSANHSES 150 DSLSQHNDFL 160 SDKDNNSNMD 170 IEERLSNNME 180 QRPSRNTGRD 190 TSRITGSHKT 200 EQRNADLTDE 210 TSRLFVKKTI 220 VVGNVSKYIP 230 PDKREENDQS 240 THKWMVYVRG 250 SRREPSINHF 260 VKKVWFFLHP 270 SYKPNDLVEV 280 REPPFHLTRR 290 GWGEFPVRVQ 300 VHFKDSQNKR 310 IDIIHNLKLD 320 RTYTGLQTLG 330 AETVVDVELH 340 RHSLGEDCIY 350 PQSSESDISD 360 APPSLPLTIP 370 APVKASSPIK 380 QSHEPVPDTS 390 VEKGFPASTE 400 AERHTPFYAL 410 PSSLERTPTK 420 MTTSQKVTFC 430 SHGNSAFQPI 440 ASSCKIVPQS 450 QVPNPESPGK 460 SFQPITMSCK 470 IVSGSPISTP 480 SPSPLPRTPT 490 STPVHVKQGT 500 AGSVINNPYV 510 IMDKQPGQVI 520 GATTPSTGSP 530 TNKISTASQV 540 SQGTGSPVPK 550 IHGSSFVTST 560 VKQEDSLFAS 570 MPPLCPIGSH 580 PKVQSPKPIT 590 GGLGAFTKVI 600 IKQEPGEAPH 610 VPATGAASQS 620 PLPQYVTVKG 630 GHMIAVSPQK 640 QVITPGEGIA 650 QSAKVQPSKV 660 VGVPVGSALP 670 STVKQAVAIS 680 GGQILVAKAS 690 SSVSKAVGPK 700 QVVTQGVAKA 710 IVSGGGGTIV 720 AQPVQTLTKA 730 QVTAAGPQKS 740 GSQGSVMATL 750 QLPATNLANL 760 ANLPPGTKLY 770 LTTNSKNPSG 780 KGKLLLIPQG 790 AILRATNNAN 800 LQSGSAASGG 810 SGAGGGGGGG 820 GGGGSGSGGG 830 GSTGGGGGTA 840 GGGTQSTAGP 850 GGISQHLTYT 860 SYILKQTPQG 870 TFLVGQPSPQ 880 TSGKQLTTGS 890 VVQGTLGVST 900 SSAQGQQTLK 910 VISGQKTTLF 920 TQAAHGGQAS 930 LMKISDSTLK 940 TVPATSQLSK 950 PGTTMLRVAG 960 GVITTATSPA 970 VALSANGPAQ 980 QSEGMAPVSS 990 STVSSVTKTS 1000 GQQQVCVSQA 1010 TVGTCKAATP 1020 TVVSATSLVP 1030 TPNPISGKAT 1040 VSGLLKIHSS 1050 QSSPQQAVLT 1060 IPSQLKPLSV 1070 NTSGGVQTIL 1080 MPVNKVVQSF 1090 STSKPPAILP 1100 VAAPTPVVPS 1110 SAPAAVAKVK 1120 TEPETPGPSC 1130 LSQEGQTAVK 1140 TEESSELGNY 1150 VIKIDHLETI 1160 QQLLTAVVKK 1170 IPLITAKSED 1180 ASCFSAKSVE 1190 QYYGWNIGKR 1200 RAAEWQRAMT 1210 MRKVLQEILE 1220 KNPRFHHLTP 1230 LKTKHIAHWC 1240 RCHGYTPPDP 1250 ESLRNDGDSI 1260 EDVLTQIDSE 1270 PECPSSFSSA 1280 DNLCRKLEDL 1290 QQFQKREPEN 1300 EEEVDILSLS 1310 EPVKINIKKE 1320 QEEKQEEVKF 1330 YLPPTPGSEF 1340 IGDVTQKIGI 1350 TLQPVALHRN 1360 VYASVVEDMI 1370 LKATEQLVND 1380 ILRQALAVGY 1390 QTASHNRIPK 1400 EITVSNIHQA 1410 ICNIPFLDFL 1420 TNKHMGILNE DQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0140672 ATAC complex
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0035267 NuA4 histone acetyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140566 histone reader activity
Molecular Function GO:0140030 modification-dependent protein binding
Molecular Function GO:0017025 TBP-class protein binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0051302 regulation of cell division
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0090043 regulation of tubulin deacetylation

Reference

PMID: N/A