Overview
| Uniprot ID | Q9ULP9 |
|---|
| Protein Name | TBC1 domain family member 24 |
|---|
| Gene Name | TBC1D24 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 84 |
IVGKIVGKHSSSCLP |
Function
May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projection development, probably through negative modulation of ARF6 function (PubMed:20727515). Required for the maintenance of postsynaptic neuron dendritic spines in the adult by suppressing ARF6 activity (PubMed:32004315). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). Promotes axonal outgrowth and membrane trafficking at the growth cone (By similarity). Positively regulates radial migration and morphological maturation of pyramidal neurons during cortical development by preventing ARF6 activation (By similarity). In one study, has been shown to inhibit the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). In another study, has been shown to positively regulate V-ATPase assembly in neurons which promotes acidification of lysosomes and synaptic vesicles (By similarity). This supports neuronal autophagy and also regulates synaptic vesicle reacidification and the maintenance of the synaptic vesicle reserve pool (By similarity). Protects neuronal cells against oxidative stress (PubMed:30335140). Involved in the maintainenance of endosomal-mediated vesicle recycling and sustained exocytosis of hair cell ribbon synapses (By similarity). Facilitates formation of tubular recycling endosomes which promotes recycling of clathrin-independent endocytosis cargo proteins back to the plasma membrane (PubMed:32475639)
Protein Sequence
10
MDSPGYNCFV
20
DKDKMDAAIQ
30
DLGPKELSCT
40
ELQELKQLAR
50
QGYWAQSHAL
60
RGKVYQRLIR
70
DIPCRTVTPD
80
ASVYSDIVGK
90
IVGKHSSSCL
100
PLPEFVDNTQ
110
VPSYCLNARG
120
EGAVRKILLC
130
LANQFPDISF
140
CPALPAVVAL
150
LLHYSIDEAE
160
CFEKACRILA
170
CNDPGRRLID
180
QSFLAFESSC
190
MTFGDLVNKY
200
CQAAHKLMVA
210
VSEDVLQVYA
220
DWQRWLFGEL
230
PLCYFARVFD
240
VFLVEGYKVL
250
YRVALAILKF
260
FHKVRAGQPL
270
ESDSVKQDIR
280
TFVRDIAKTV
290
SPEKLLEKAF
300
AIRLFSRKEI
310
QLLQMANEKA
320
LKQKGITVKQ
330
KSVSLSKRQF
340
VHLAVHAENF
350
RSEIVSVREM
360
RDIWSWVPER
370
FALCQPLLLF
380
SSLQHGYSLA
390
RFYFQCEGHE
400
PTLLLIKTTQ
410
KEVCGAYLST
420
DWSERNKFGG
430
KLGFFGTGEC
440
FVFRLQPEVQ
450
RYEWVVIKHP
460
ELTKPPPLMA
470
AEPTAPLSHS
480
ASSDPADRLS
490
PFLAARHFNL
500
PSKTESMFMA
510
GGSDCLIVGG
520
GGGQALYIDG
530
DLNRGRTSHC
540
DTFNNQPLCS
550
ENFLIAAVEA
WGFQDPDTQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0031594 |
neuromuscular junction |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0043195 |
terminal bouton |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Biological Process |
GO:0034599 |
cellular response to oxidative stress |
| Biological Process |
GO:0031175 |
neuron projection development |
| Biological Process |
GO:0050775 |
positive regulation of dendrite morphogenesis |
| Biological Process |
GO:2000463 |
positive regulation of excitatory postsynaptic potential |
| Biological Process |
GO:2001224 |
positive regulation of neuron migration |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.