Overview
| Uniprot ID | Q9ULR0 |
|---|
| Protein Name | Pre-mRNA-splicing factor ISY1 homolog |
|---|
| Gene Name | ISY1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 127 |
YKYFGAAKDLPGVRE |
| 7 |
*MARNAEKAMTALAR |
Function
Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome
Protein Sequence
10
MARNAEKAMT
20
ALARFRQAQL
30
EEGKVKERRP
40
FLASECTELP
50
KAEKWRRQII
60
GEISKKVAQI
70
QNAGLGEFRI
80
RDLNDEINKL
90
LREKGHWEVR
100
IKELGGPDYG
110
KVGPKMLDHE
120
GKEVPGNRGY
130
KYFGAAKDLP
140
GVRELFEKEP
150
LPPPRKTRAE
160
LMKAIDFEYY
170
GYLDEDDGVI
180
VPLEQEYEKK
190
LRAELVEKWK
200
AEREARLARG
210
EKEEEEEEEE
220
EINIYAVTEE
230
ESDEEGSQEK
240
GGDDSQQKFI
250
AHVPVPSQQE
260
IEEALVRRKK
270
MELLQKYASE
280
TLQAQSEEAR
RLLGY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071013 |
catalytic step 2 spliceosome |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0071014 |
post-mRNA release spliceosomal complex |
| Cellular Component |
GO:0071020 |
post-spliceosomal complex |
| Cellular Component |
GO:0000974 |
Prp19 complex |
| Cellular Component |
GO:0071006 |
U2-type catalytic step 1 spliceosome |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0000350 |
generation of catalytic spliceosome for second transesterification step |
| Biological Process |
GO:0000389 |
mRNA 3'-splice site recognition |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.