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Overview

Uniprot IDQ9ULT8
Protein NameE3 ubiquitin-protein ligase HECTD1
Gene NameHECTD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1272 LVRSQVLKYMVPGAR

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283)

Protein Sequence

10 MADVDPDTLL 20 EWLQMGQGDE 30 RDMQLIALEQ 40 LCMLLLMSDN 50 VDRCFETCPP 60 RTFLPALCKI 70 FLDESAPDNV 80 LEVTARAITY 90 YLDVSAECTR 100 RIVGVDGAIK 110 ALCNRLVVVE 120 LNNRTSRDLA 130 EQCVKVLELI 140 CTRESGAVFE 150 AGGLNCVLTF 160 IRDSGHLVHK 170 DTLHSAMAVV 180 SRLCGKMEPQ 190 DSSLEICVES 200 LSSLLKHEDH 210 QVSDGALRCF 220 ASLADRFTRR 230 GVDPAPLAKH 240 GLTEELLSRM 250 AAAGGTVSGP 260 SSACKPGRST 270 TGAPSTTADS 280 KLSNQVSTIV 290 SLLSTLCRGS 300 PVVTHDLLRS 310 ELPDSIESAL 320 QGDERCVLDT 330 MRLVDLLLVL 340 LFEGRKALPK 350 SSAGSTGRIP 360 GLRRLDSSGE 370 RSHRQLIDCI 380 RSKDTDALID 390 AIDTGAFEVN 400 FMDDVGQTLL 410 NWASAFGTQE 420 MVEFLCERGA 430 DVNRGQRSSS 440 LHYAACFGRP 450 QVAKTLLRHG 460 ANPDLRDEDG 470 KTPLDKARER 480 GHSEVVAILQ 490 SPGDWMCPVN 500 KGDDKKKKDT 510 NKDEEECNEP 520 KGDPEMAPIY 530 LKRLLPVFAQ 540 TFQQTMLPSI 550 RKASLALIRK 560 MIHFCSEALL 570 KEVCDSDVGH 580 NLPTILVEIT 590 ATVLDQEDDD 600 DGHLLALQII 610 RDLVDKGGDI 620 FLDQLARLGV 630 ISKVSTLAGP 640 SSDDENEEES 650 KPEKEDEPQE 660 DAKELQQGKP 670 YHWRDWSIIR 680 GRDCLYIWSD 690 AAALELSNGS 700 NGWFRFILDG 710 KLATMYSSGS 720 PEGGSDSSES 730 RSEFLEKLQR 740 ARGQVKPSTS 750 SQPILSAPGP 760 TKLTVGNWSL 770 TCLKEGEIAI 780 HNSDGQQATI 790 LKEDLPGFVF 800 ESNRGTKHSF 810 TAETSLGSEF 820 VTGWTGKRGR 830 KLKSKLEKTK 840 QKVRTMARDL 850 YDDHFKAVES 860 MPRGVVVTLR 870 NIATQLESSW 880 ELHTNRQCIE 890 SENTWRDLMK 900 TALENLIVLL 910 KDENTISPYE 920 MCSSGLVQAL 930 LTVLNNSMDL 940 DMKQDCSQLV 950 ERINVFKTAF 960 SENEDDESRP 970 AVALIRKLIA 980 VLESIERLPL 990 HLYDTPGSTY 1000 NLQILTRRLR 1010 FRLERAPGET 1020 ALIDRTGRML 1030 KMEPLATVES 1040 LEQYLLKMVA 1050 KQWYDFDRSS 1060 FVFVRKLREG 1070 QNFIFRHQHD 1080 FDENGIIYWI 1090 GTNAKTAYEW 1100 VNPAAYGLVV 1110 VTSSEGRNLP 1120 YGRLEDILSR 1130 DNSALNCHSN 1140 DDKNAWFAID 1150 LGLWVIPSAY 1160 TLRHARGYGR 1170 SALRNWVFQV 1180 SKDGQNWTSL 1190 YTHVDDCSLN 1200 EPGSTATWPL 1210 DPPKDEKQGW 1220 RHVRIKQMGK 1230 NASGQTHYLS 1240 LSGFELYGTV 1250 NGVCEDQLGK 1260 AAKEAEANLR 1270 RQRRLVRSQV 1280 LKYMVPGARV 1290 IRGLDWKWRD 1300 QDGSPQGEGT 1310 VTGELHNGWI 1320 DVTWDAGGSN 1330 SYRMGAEGKF 1340 DLKLAPGYDP 1350 DTVASPKPVS 1360 STVSGTTQSW 1370 SSLVKNNCPD 1380 KTSAAAGSSS 1390 RKGSSSSVCS 1400 VASSSDISLG 1410 STKTERRSEI 1420 VMEHSIVSGA 1430 DVHEPIVVLS 1440 SAENVPQTEV 1450 GSSSSASTST 1460 LTAETGSENA 1470 ERKLGPDSSV 1480 RTPGESSAIS 1490 MGIVSVSSPD 1500 VSSVSELTNK 1510 EAASQRPLSS 1520 SASNRLSVSS 1530 LLAAGAPMSS 1540 SASVPNLSSR 1550 ETSSLESFVR 1560 RVANIARTNA 1570 TNNMNLSRSS 1580 SDNNTNTLGR 1590 NVMSTATSPL 1600 MGAQSFPNLT 1610 TPGTTSTVTM 1620 STSSVTSSSN 1630 VATATTVLSV 1640 GQSLSNTLTT 1650 SLTSTSSESD 1660 TGQEAEYSLY 1670 DFLDSCRAST 1680 LLAELDDDED 1690 LPEPDEEDDE 1700 NEDDNQEDQE 1710 YEEVMILRRP 1720 SLQRRAGSRS 1730 DVTHHAVTSQ 1740 LPQVPAGAGS 1750 RPIGEQEEEE 1760 YETKGGRRRT 1770 WDDDYVLKRQ 1780 FSALVPAFDP 1790 RPGRTNVQQT 1800 TDLEIPPPGT 1810 PHSELLEEVE 1820 CTPSPRLALT 1830 LKVTGLGTTR 1840 EVELPLTNFR 1850 STIFYYVQKL 1860 LQLSCNGNVK 1870 SDKLRRIWEP 1880 TYTIMYREMK 1890 DSDKEKENGK 1900 MGCWSIEHVE 1910 QYLGTDELPK 1920 NDLITYLQKN 1930 ADAAFLRHWK 1940 LTGTNKSIRK 1950 NRNCSQLIAA 1960 YKDFCEHGTK 1970 SGLNQGAIST 1980 LQSSDILNLT 1990 KEQPQAKAGN 2000 GQNSCGVEDV 2010 LQLLRILYIV 2020 ASDPYSRISQ 2030 EDGDEQPQFT 2040 FPPDEFTSKK 2050 ITTKILQQIE 2060 EPLALASGAL 2070 PDWCEQLTSK 2080 CPFLIPFETR 2090 QLYFTCTAFG 2100 ASRAIVWLQN 2110 RREATVERTR 2120 TTSSVRRDDP 2130 GEFRVGRLKH 2140 ERVKVPRGES 2150 LMEWAENVMQ 2160 IHADRKSVLE 2170 VEFLGEEGTG 2180 LGPTLEFYAL 2190 VAAEFQRTDL 2200 GAWLCDDNFP 2210 DDESRHVDLG 2220 GGLKPPGYYV 2230 QRSCGLFTAP 2240 FPQDSDELER 2250 ITKLFHFLGI 2260 FLAKCIQDNR 2270 LVDLPISKPF 2280 FKLMCMGDIK 2290 SNMSKLIYES 2300 RGDRDLHCTE 2310 SQSEASTEEG 2320 HDSLSVGSFE 2330 EDSKSEFILD 2340 PPKPKPPAWF 2350 NGILTWEDFE 2360 LVNPHRARFL 2370 KEIKDLAIKR 2380 RQILSNKGLS 2390 EDEKNTKLQE 2400 LVLKNPSGSG 2410 PPLSIEDLGL 2420 NFQFCPSSRI 2430 YGFTAVDLKP 2440 SGEDEMITMD 2450 NAEEYVDLMF 2460 DFCMHTGIQK 2470 QMEAFRDGFN 2480 KVFPMEKLSS 2490 FSHEEVQMIL 2500 CGNQSPSWAA 2510 EDIINYTEPK 2520 LGYTRDSPGF 2530 LRFVRVLCGM 2540 SSDERKAFLQ 2550 FTTGCSTLPP 2560 GGLANLHPRL 2570 TVVRKVDATD 2580 ASYPSVNTCV 2590 HYLKLPEYSS 2600 EEIMRERLLA 2610 ATMEKGFHLN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Biological Process GO:0035904 aorta development
Biological Process GO:0003170 heart valve development
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0003281 ventricular septum development

Reference

PMID: N/A