Search Results

Overview

Uniprot IDQ9ULU8
Protein NameCalcium-dependent secretion activator 1
Gene NameCADPS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
501 WHKMTVSKNCPDQDL

Function

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity)

Protein Sequence

10 MLDPSSSEEE 20 SDEIVEEESG 30 KEVLGSAPSG 40 ARLSPSRTSE 50 GSAGSAGLGG 60 GGAGAGAGVG 70 AGGGGGSGAS 80 SGGGAGGLQP 90 SSRAGGGRPS 100 SPSPSVVSEK 110 EKEELERLQK 120 EEEERKKRLQ 130 LYVFVMRCIA 140 YPFNAKQPTD 150 MARRQQKISK 160 QQLQTVKDRF 170 QAFLNGETQI 180 MADEAFMNAV 190 QSYYEVFLKS 200 DRVARMVQSG 210 GCSANDSREV 220 FKKHIEKRVR 230 SLPEIDGLSK 240 ETVLSSWMAK 250 FDAIYRGEED 260 PRKQQARMTA 270 SAASELILSK 280 EQLYEMFQNI 290 LGIKKFEHQL 300 LYNACQLDNP 310 DEQAAQIRRE 320 LDGRLQMADQ 330 IARERKFPKF 340 VSKEMENMYI 350 EELKSSVNLL 360 MANLESMPVS 370 KGGEFKLQKL 380 KRSHNASIID 390 MGEESENQLS 400 KSDVVLSFSL 410 EVVIMEVQGL 420 KSLAPNRIVY 430 CTMEVEGGEK 440 LQTDQAEASK 450 PTWGTQGDFS 460 TTHALPAVKV 470 KLFTESTGVL 480 ALEDKELGRV 490 ILHPTPNSPK 500 QSEWHKMTVS 510 KNCPDQDLKI 520 KLAVRMDKPQ 530 NMKHSGYLWA 540 IGKNVWKRWK 550 KRFFVLVQVS 560 QYTFAMCSYR 570 EKKAEPQELL 580 QLDGYTVDYT 590 DPQPGLEGGR 600 AFFNAVKEGD 610 TVIFASDDEQ 620 DRILWVQAMY 630 RATGQSHKPV 640 PPTQVQKLNA 650 KGGNVPQLDA 660 PISQFYADRA 670 QKHGMDEFIS 680 SNPCNFDHAS 690 LFEMVQRLTL 700 DHRLNDSYSC 710 LGWFSPGQVF 720 VLDEYCARNG 730 VRGCHRHLCY 740 LRDLLERAEN 750 GAMIDPTLLH 760 YSFAFCASHV 770 HGNRPDGIGT 780 VTVEEKERFE 790 EIKERLRVLL 800 ENQITHFRYC 810 FPFGRPEGAL 820 KATLSLLERV 830 LMKDIVTPVP 840 QEEVKTVIRK 850 CLEQAALVNY 860 SRLSEYAKIE 870 ENQKDAENVG 880 RLITPAKKLE 890 DTIRLAELVI 900 EVLQQNEEHH 910 AEPHVDKGEA 920 FAWWSDLMVE 930 HAETFLSLFA 940 VDMDAALEVQ 950 PPDTWDSFPL 960 FQLLNDFLRT 970 DYNLCNGKFH 980 KHLQDLFAPL 990 VVRYVDLMES 1000 SIAQSIHRGF 1010 ERESWEPVKS 1020 LTSNLPNVNL 1030 PNVNLPKVPN 1040 LPVNIPLGIP 1050 QMPTFSAPSW 1060 MAAIYDADNG 1070 SGTSEDLFWK 1080 LDALQTFIRD 1090 LHWPEEEFGK 1100 HLEQRLKLMA 1110 SDMIESCVKR 1120 TRIAFEVKLQ 1130 KTSRSTDFRV 1140 PQSICTMFNV 1150 MVDAKAQSTK 1160 LCSMEMGQEH 1170 QYHSKIDELI 1180 EETVKEMITL 1190 LVAKFVTILE 1200 GVLAKLSRYD 1210 EGTLFSSFLS 1220 FTVKAASKYV 1230 DVPKPGMDVA 1240 DAYVTFVRHS 1250 QDVLRDKVNE 1260 EMYIERLFDQ 1270 WYNSSMNVIC 1280 TWLTDRMDLQ 1290 LHIYQLKTLI 1300 RMVKKTYRDF 1310 RLQGVLDSTL 1320 NSKTYETIRN 1330 RLTVEEATAS 1340 VSEGGGLQGI 1350 SMKDSDEEDE EDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0099012 neuronal dense core vesicle membrane
Cellular Component GO:0098793 presynapse
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:1990504 dense core granule exocytosis
Biological Process GO:0006887 exocytosis
Biological Process GO:0045921 positive regulation of exocytosis
Biological Process GO:0015031 protein transport
Biological Process GO:0016079 synaptic vesicle exocytosis

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.