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Overview

Uniprot IDQ9ULV0
Protein NameUnconventional myosin-Vb
Gene NameMYO5B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
515 DLLDEECKVPKGTDQ

Function

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459)

Protein Sequence

10 MSVGELYSQC 20 TRVWIPDPDE 30 VWRSAELTKD 40 YKEGDKSLQL 50 RLEDETILEY 60 PIDVQRNQLP 70 FLRNPDILVG 80 ENDLTALSYL 90 HEPAVLHNLK 100 VRFLESNHIY 110 TYCGIVLVAI 120 NPYEQLPIYG 130 QDVIYTYSGQ 140 NMGDMDPHIF 150 AVAEEAYKQM 160 ARDEKNQSII 170 VSGESGAGKT 180 VSAKYAMRYF 190 ATVGGSASET 200 NIEEKVLASS 210 PIMEAIGNAK 220 TTRNDNSSRF 230 GKYIQIGFDK 240 RYHIIGANMR 250 TYLLEKSRVV 260 FQADDERNYH 270 IFYQLCAAAG 280 LPEFKELALT 290 SAEDFFYTSQ 300 GGDTSIEGVD 310 DAEDFEKTRQ 320 AFTLLGVKES 330 HQMSIFKIIA 340 SILHLGSVAI 350 QAERDGDSCS 360 ISPQDVYLSN 370 FCRLLGVEHS 380 QMEHWLCHRK 390 LVTTSETYVK 400 TMSLQQVINA 410 RNALAKHIYA 420 QLFGWIVEHI 430 NKALHTSLKQ 440 HSFIGVLDIY 450 GFETFEVNSF 460 EQFCINYANE 470 KLQQQFNSHV 480 FKLEQEEYMK 490 EQIPWTLIDF 500 YDNQPCIDLI 510 EAKLGILDLL 520 DEECKVPKGT 530 DQNWAQKLYD 540 RHSSSQHFQK 550 PRMSNTAFII 560 VHFADKVEYL 570 SDGFLEKNRD 580 TVYEEQINIL 590 KASKFPLVAD 600 LFHDDKDPVP 610 ATTPGKGSSS 620 KISVRSARPP 630 MKVSNKEHKK 640 TVGHQFRTSL 650 HLLMETLNAT 660 TPHYVRCIKP 670 NDEKLPFHFD 680 PKRAVQQLRA 690 CGVLETIRIS 700 AAGYPSRWAY 710 HDFFNRYRVL 720 VKKRELANTD 730 KKAICRSVLE 740 NLIKDPDKFQ 750 FGRTKIFFRA 760 GQVAYLEKLR 770 ADKFRTATIM 780 IQKTVRGWLQ 790 KVKYHRLKGA 800 TLTLQRYCRG 810 HLARRLAEHL 820 RRIRAAVVLQ 830 KHYRMQRARQ 840 AYQRVRRAAV 850 VIQAFTRAMF 860 VRRTYRQVLM 870 EHKATTIQKH 880 VRGWMARRHF 890 QRLRDAAIVI 900 QCAFRMLKAR 910 RELKALRIEA 920 RSAEHLKRLN 930 VGMENKVVQL 940 QRKIDEQNKE 950 FKTLSEQLSV 960 TTSTYTMEVE 970 RLKKELVHYQ 980 QSPGEDTSLR 990 LQEEVESLRT 1000 ELQRAHSERK 1010 ILEDAHSREK 1020 DELRKRVADL 1030 EQENALLKDE 1040 KEQLNNQILC 1050 QSKDEFAQNS 1060 VKENLMKKEL 1070 EEERSRYQNL 1080 VKEYSQLEQR 1090 YDNLRDEMTI 1100 IKQTPGHRRN 1110 PSNQSSLESD 1120 SNYPSISTSE 1130 IGDTEDALQQ 1140 VEEIGLEKAA 1150 MDMTVFLKLQ 1160 KRVRELEQER 1170 KKLQVQLEKR 1180 EQQDSKKVQA 1190 EPPQTDIDLD 1200 PNADLAYNSL 1210 KRQELESENK 1220 KLKNDLNELR 1230 KAVADQATQN 1240 NSSHGSPDSY 1250 SLLLNQLKLA 1260 HEELEVRKEE 1270 VLILRTQIVS 1280 ADQRRLAGRN 1290 AEPNINARSS 1300 WPNSEKHVDQ 1310 EDAIEAYHGV 1320 CQTNSKTEDW 1330 GYLNEDGELG 1340 LAYQGLKQVA 1350 RLLEAQLQAQ 1360 SLEHEEEVEH 1370 LKAQLEALKE 1380 EMDKQQQTFC 1390 QTLLLSPEAQ 1400 VEFGVQQEIS 1410 RLTNENLDLK 1420 ELVEKLEKNE 1430 RKLKKQLKIY 1440 MKKAQDLEAA 1450 QALAQSERKR 1460 HELNRQVTVQ 1470 RKEKDFQGML 1480 EYHKEDEALL 1490 IRNLVTDLKP 1500 QMLSGTVPCL 1510 PAYILYMCIR 1520 HADYTNDDLK 1530 VHSLLTSTIN 1540 GIKKVLKKHN 1550 DDFEMTSFWL 1560 SNTCRLLHCL 1570 KQYSGDEGFM 1580 TQNTAKQNEH 1590 CLKNFDLTEY 1600 RQVLSDLSIQ 1610 IYQQLIKIAE 1620 GVLQPMIVSA 1630 MLENESIQGL 1640 SGVKPTGYRK 1650 RSSSMADGDN 1660 SYCLEAIIRQ 1670 MNAFHTVMCD 1680 QGLDPEIILQ 1690 VFKQLFYMIN 1700 AVTLNNLLLR 1710 KDVCSWSTGM 1720 QLRYNISQLE 1730 EWLRGRNLHQ 1740 SGAVQTMEPL 1750 IQAAQLLQLK 1760 KKTQEDAEAI 1770 CSLCTSLSTQ 1780 QIVKILNLYT 1790 PLNEFEERVT 1800 VAFIRTIQAQ 1810 LQERNDPQQL 1820 LLDAKHMFPV 1830 LFPFNPSSLT 1840 MDSIHIPACL NLEFLNEV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0045179 apical cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0006897 endocytosis
Biological Process GO:0016197 endosomal transport
Biological Process GO:0015031 protein transport
Biological Process GO:0003091 renal water homeostasis
Biological Process GO:0016192 vesicle-mediated transport

Reference

PMID: N/A