Search Results
Overview
| Uniprot ID | Q9ULV4 |
|---|---|
| Protein Name | Coronin-1C |
| Gene Name | CORO1C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 353 | IIMTVPRKSDLFQDD |
| 391 | DPILISLKHGYIPGK |
| 398 | KHGYIPGKNRDLKVV |
| 407 | RDLKVVKKNILDSKP |
| 413 | KKNILDSKPTANKKC |
| 419 | SKPTANKKCDLISIP |
| 428 | DLISIPKKTTDTASV |
| 452 | LKEIKSIKDTICNQD |
Function
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). Interacts with GDP-bound RAB44 in bone marrow macrophages to promote osteoclastogenesis (By similarity). Involved in the migration and chemotaxis of macrophages (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030017 | sarcomere |
| Biological Process | GO:0007015 | actin filament organization |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0016600 | flotillin complex |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0090630 | activation of GTPase activity |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:0140285 | endosome fission |
| Biological Process | GO:0097750 | endosome membrane tubulation |
| Biological Process | GO:0045184 | establishment of protein localization |
| Biological Process | GO:0048246 | macrophage chemotaxis |
| Biological Process | GO:0090148 | membrane fission |
| Biological Process | GO:0010633 | negative regulation of epithelial cell migration |
| Biological Process | GO:0051895 | negative regulation of focal adhesion assembly |
| Biological Process | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| Biological Process | GO:0001933 | negative regulation of protein phosphorylation |
| Biological Process | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0001755 | neural crest cell migration |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:2000394 | positive regulation of lamellipodium morphogenesis |
| Biological Process | GO:0045672 | positive regulation of osteoclast differentiation |
| Biological Process | GO:0010632 | regulation of epithelial cell migration |
| Biological Process | GO:0010762 | regulation of fibroblast migration |
| Biological Process | GO:0051893 | regulation of focal adhesion assembly |
| Biological Process | GO:0001932 | regulation of protein phosphorylation |
| Biological Process | GO:1900027 | regulation of ruffle assembly |
| Biological Process | GO:1900024 | regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0007165 | signal transduction |
Reference
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[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
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[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.