Overview
| Uniprot ID | Q9UM13 |
|---|
| Protein Name | Anaphase-promoting complex subunit 10 |
|---|
| Gene Name | ANAPC10 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 169 |
VEESSIGKFPRCTTI |
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861)
Protein Sequence
10
MTTPNKTPPG
20
ADPKQLERTG
30
TVREIGSQAV
40
WSLSSCKPGF
50
GVDQLRDDNL
60
ETYWQSDGSQ
70
PHLVNIQFRR
80
KTTVKTLCIY
90
ADYKSDESYT
100
PSKISVRVGN
110
NFHNLQEIRQ
120
LELVEPSGWI
130
HVPLTDNHKK
140
PTRTFMIQIA
150
VLANHQNGRD
160
THMRQIKIYT
170
PVEESSIGKF
180
PRCTTIDFMM
YRSIR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005680 |
anaphase-promoting complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0031145 |
anaphase-promoting complex-dependent catabolic process |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0141198 |
protein branched polyubiquitination |
| Biological Process |
GO:0070979 |
protein K11-linked ubiquitination |
| Biological Process |
GO:0070936 |
protein K48-linked ubiquitination |
| Biological Process |
GO:0051445 |
regulation of meiotic cell cycle |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
Reference
PMID: N/A