Search Results

Overview

Uniprot ID	Q9UM54
Protein Name	Unconventional myosin-VI
Gene Name	MYO6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1076	GPAVLATKAAAGTKK
403	LTTAGGTKGTVIKVP

Function

Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370)

Protein Sequence

10 MEDGKPVWAP 20 HPTDGFQMGN 30 IVDIGPDSLT 40 IEPLNQKGKT 50 FLALINQVFP 60 AEEDSKKDVE 70 DNCSLMYLNE 80 ATLLHNIKVR 90 YSKDRIYTYV 100 ANILIAVNPY 110 FDIPKIYSSE 120 AIKSYQGKSL 130 GTRPPHVFAI 140 ADKAFRDMKV 150 LKMSQSIIVS 160 GESGAGKTEN 170 TKFVLRYLTE 180 SYGTGQDIDD 190 RIVEANPLLE 200 AFGNAKTVRN 210 NNSSRFGKFV 220 EIHFNEKSSV 230 VGGFVSHYLL 240 EKSRICVQGK 250 EERNYHIFYR 260 LCAGASEDIR 270 EKLHLSSPDN 280 FRYLNRGCTR 290 YFANKETDKQ 300 ILQNRKSPEY 310 LKAGSMKDPL 320 LDDHGDFIRM 330 CTAMKKIGLD 340 DEEKLDLFRV 350 VAGVLHLGNI 360 DFEEAGSTSG 370 GCNLKNKSAQ 380 SLEYCAELLG 390 LDQDDLRVSL 400 TTRVMLTTAG 410 GTKGTVIKVP 420 LKVEQANNAR 430 DALAKTVYSH 440 LFDHVVNRVN 450 QCFPFETSSY 460 FIGVLDIAGF 470 EYFEHNSFEQ 480 FCINYCNEKL 490 QQFFNERILK 500 EEQELYQKEG 510 LGVNEVHYVD 520 NQDCIDLIEA 530 KLVGILDILD 540 EENRLPQPSD 550 QHFTSAVHQK 560 HKDHFRLTIP 570 RKSKLAVHRN 580 IRDDEGFIIR 590 HFAGAVCYET 600 TQFVEKNNDA 610 LHMSLESLIC 620 ESRDKFIREL 630 FESSTNNNKD 640 TKQKAGKLSF 650 ISVGNKFKTQ 660 LNLLLDKLRS 670 TGASFIRCIK 680 PNLKMTSHHF 690 EGAQILSQLQ 700 CSGMVSVLDL 710 MQGGYPSRAS 720 FHELYNMYKK 730 YMPDKLARLD 740 PRLFCKALFK 750 ALGLNENDYK 760 FGLTKVFFRP 770 GKFAEFDQIM 780 KSDPDHLAEL 790 VKRVNHWLTC 800 SRWKKVQWCS 810 LSVIKLKNKI 820 KYRAEACIKM 830 QKTIRMWLCK 840 RRHKPRIDGL 850 VKVGTLKKRL 860 DKFNEVVSVL 870 KDGKPEMNKQ 880 IKNLEISIDT 890 LMAKIKSTMM 900 TQEQIQKEYD 910 ALVKSSEELL 920 SALQKKKQQE 930 EEAERLRRIQ 940 EEMEKERKRR 950 EEDEKRRRKE 960 EEERRMKLEM 970 EAKRKQEEEE 980 RKKREDDEKR 990 IQAEVEAQLA 1000 RQKEEESQQQ 1010 AVLEQERRDR 1020 ELALRIAQSE 1030 AELISDEAQA 1040 DLALRRSLDS 1050 YPVSKNDGTR 1060 PKMTPEQMAK 1070 EMSEFLSRGP 1080 AVLATKAAAG 1090 TKKYDLSKWK 1100 YAELRDTINT 1110 SCDIELLAAC 1120 REEFHRRLKV 1130 YHAWKSKNKK 1140 RNTETEQRAP 1150 KSVTDYDFAP 1160 FLNNSPQQNP 1170 AAQIPARQRE 1180 IEMNRQQRFF 1190 RIPFIRPADQ 1200 YKDPQSKKKG 1210 WWYAHFDGPW 1220 IARQMELHPD 1230 KPPILLVAGK 1240 DDMEMCELNL 1250 EETGLTRKRG 1260 AEILPRQFEE 1270 IWERCGGIQY 1280 LQNAIESRQA 1290 RPTYATAMLQ SLLK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005884	actin filament
Cellular Component	GO:0005776	autophagosome
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005905	clathrin-coated pit
Cellular Component	GO:0030665	clathrin-coated vesicle membrane
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030139	endocytic vesicle
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031941	filamentous actin
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005902	microvillus
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0032587	ruffle membrane
Cellular Component	GO:0016461	unconventional myosin complex
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0043531	ADP binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0003774	cytoskeletal motor activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0000146	microfilament motor activity
Molecular Function	GO:0060001	minus-end directed microfilament motor activity
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0030048	actin filament-based movement
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation
Biological Process	GO:0042472	inner ear morphogenesis
Biological Process	GO:0008104	intracellular protein localization
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0051046	regulation of secretion
Biological Process	GO:0007266	Rho protein signal transduction
Biological Process	GO:0007605	sensory perception of sound
Biological Process	GO:0031106	septin ring organization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.