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Overview

Uniprot IDQ9UMN6
Protein NameHistone-lysine N-methyltransferase 2B
Gene NameKMT2B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1934 RWASPPLKTSPQLRV
2196 SKIILVNKLGQVFVK

Function

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity)

Protein Sequence

10 MAAAAGGGSC 20 PGPGSARGRF 30 PGRPRGAGGG 40 GGRGGRGNGA 50 ERVRVALRRG 60 GGATGPGGAE 70 PGEDTALLRL 80 LGLRRGLRRL 90 RRLWAGPRVQ 100 RGRGRGRGRG 110 WGPSRGCVPE 120 EESSDGESDE 130 EEFQGFHSDE 140 DVAPSSLRSA 150 LRSQRGRAPR 160 GRGRKHKTTP 170 LPPPRLADVA 180 PTPPKTPARK 190 RGEEGTERMV 200 QALTELLRRA 210 QAPQAPRSRA 220 CEPSTPRRSR 230 GRPPGRPAGP 240 CRRKQQAVVV 250 AEAAVTIPKP 260 EPPPPVVPVK 270 HQTGSWKCKE 280 GPGPGPGTPR 290 RGGQSSRGGR 300 GGRGRGRGGG 310 LPFVIKFVSR 320 AKKVKMGQLS 330 LGLESGQGQG 340 QHEESWQDVP 350 QRRVGSGQGG 360 SPCWKKQEQK 370 LDDEEEEKKE 380 EEEKDKEGEE 390 KEERAVAEEM 400 MPAAEKEEAK 410 LPPPPLTPPA 420 PSPPPPLPPP 430 STSPPPPLCP 440 PPPPPVSPPP 450 LPSPPPPPAQ 460 EEQEESPPPV 470 VPATCSRKRG 480 RPPLTPSQRA 490 EREAARAGPE 500 GTSPPTPTPS 510 TATGGPPEDS 520 PTVAPKSTTF 530 LKNIRQFIMP 540 VVSARSSRVI 550 KTPRRFMDED 560 PPKPPKVEVS 570 PVLRPPITTS 580 PPVPQEPAPV 590 PSPPRAPTPP 600 STPVPLPEKR 610 RSILREPTFR 620 WTSLTRELPP 630 PPPAPPPPPA 640 PSPPPAPATS 650 SRRPLLLRAP 660 QFTPSEAHLK 670 IYESVLTPPP 680 LGAPEAPEPE 690 PPPADDSPAE 700 PEPRAVGRTN 710 HLSLPRFAPV 720 VTTPVKAEVS 730 PHGAPALSNG 740 PQTQAQLLQP 750 LQALQTQLLP 760 QALPPPQPQL 770 QPPPSPQQMP 780 PLEKARIAGV 790 GSLPLSGVEE 800 KMFSLLKRAK 810 VQLFKIDQQQ 820 QQKVAASMPL 830 SPGGQMEEVA 840 GAVKQISDRG 850 PVRSEDESVE 860 AKRERPSGPE 870 SPVQGPRIKH 880 VCRHAAVALG 890 QARAMVPEDV 900 PRLSALPLRD 910 RQDLATEDTS 920 SASETESVPS 930 RSRRGKVEAA 940 GPGGESEPTG 950 SGGTLAHTPR 960 RSLPSHHGKK 970 MRMARCGHCR 980 GCLRVQDCGS 990 CVNCLDKPKF 1000 GGPNTKKQCC 1010 VYRKCDKIEA 1020 RKMERLAKKG 1030 RTIVKTLLPW 1040 DSDESPEASP 1050 GPPGPRRGAG 1060 AGGPREEVVA 1070 HPGPEEQDSL 1080 LQRKSARRCV 1090 KQRPSYDIFE 1100 DSDDSEPGGP 1110 PAPRRRTPRE 1120 NELPLPEPEE 1130 QSRPRKPTLQ 1140 PVLQLKARRR 1150 LDKDALAPGP 1160 FASFPNGWTG 1170 KQKSPDGVHR 1180 VRVDFKEDCD 1190 LENVWLMGGL 1200 SVLTSVPGGP 1210 PMVCLLCASK 1220 GLHELVFCQV 1230 CCDPFHPFCL 1240 EEAERPLPQH 1250 HDTWCCRRCK 1260 FCHVCGRKGR 1270 GSKHLLECER 1280 CRHAYHPACL 1290 GPSYPTRATR 1300 KRRHWICSAC 1310 VRCKSCGATP 1320 GKNWDVEWSG 1330 DYSLCPRCTQ 1340 LYEKGNYCPI 1350 CTRCYEDNDY 1360 ESKMMQCAQC 1370 DHWVHAKCEG 1380 LSDEDYEILS 1390 GLPDSVLYTC 1400 GPCAGAAQPR 1410 WREALSGALQ 1420 GGLRQVLQGL 1430 LSSKVVGPLL 1440 LCTQCGPDGK 1450 QLHPGPCGLQ 1460 AVSQRFEDGH 1470 YKSVHSFMED 1480 MVGILMRHSE 1490 EGETPDRRAG 1500 GQMKGLLLKL 1510 LESAFGWFDA 1520 HDPKYWRRST 1530 RLPNGVLPNA 1540 VLPPSLDHVY 1550 AQWRQQEPET 1560 PESGQPPGDP 1570 SAAFQGKDPA 1580 AFSHLEDPRQ 1590 CALCLKYGDA 1600 DSKEAGRLLY 1610 IGQNEWTHVN 1620 CAIWSAEVFE 1630 ENDGSLKNVH 1640 AAVARGRQMR 1650 CELCLKPGAT 1660 VGCCLSSCLS 1670 NFHFMCARAS 1680 YCIFQDDKKV 1690 FCQKHTDLLD 1700 GKEIVNPDGF 1710 DVLRRVYVDF 1720 EGINFKRKFL 1730 TGLEPDAINV 1740 LIGSIRIDSL 1750 GTLSDLSDCE 1760 GRLFPIGYQC 1770 SRLYWSTVDA 1780 RRRCWYRCRI 1790 LEYRPWGPRE 1800 EPAHLEAAEE 1810 NQTIVHSPAP 1820 SSEPPGGEDP 1830 PLDTDVLVPG 1840 APERHSPIQN 1850 LDPPLRPDSG 1860 SAPPPAPRSF 1870 SGARIKVPNY 1880 SPSRRPLGGV 1890 SFGPLPSPGS 1900 PSSLTHHIPT 1910 VGDPDFPAPP 1920 RRSRRPSPLA 1930 PRPPPSRWAS 1940 PPLKTSPQLR 1950 VPPPTSVVTA 1960 LTPTSGELAP 1970 PGPAPSPPPP 1980 EDLGPDFEDM 1990 EVVSGLSAAD 2000 LDFAASLLGT 2010 EPFQEEIVAA 2020 GAMGSSHGGP 2030 GDSSEEESSP 2040 TSRYIHFPVT 2050 VVSAPGLAPS 2060 ATPGAPRIEQ 2070 LDGVDDGTDS 2080 EAEAVQQPRG 2090 QGTPPSGPGV 2100 VRAGVLGAAG 2110 DRARPPEDLP 2120 SEIVDFVLKN 2130 LGGPGDGGAG 2140 PREESLPPAP 2150 PLANGSQPSQ 2160 GLTASPADPT 2170 RTFAWLPGAP 2180 GVRVLSLGPA 2190 PEPPKPATSK 2200 IILVNKLGQV 2210 FVKMAGEGEP 2220 VPPPVKQPPL 2230 PPTISPTAPT 2240 SWTLPPGPLL 2250 GVLPVVGVVR 2260 PAPPPPPPPL 2270 TLVLSSGPAS 2280 PPRQAIRVKR 2290 VSTFSGRSPP 2300 APPPYKAPRL 2310 DEDGEASEDT 2320 PQVPGLGSGG 2330 FSRVRMKTPT 2340 VRGVLDLDRP 2350 GEPAGEESPG 2360 PLQERSPLLP 2370 LPEDGPPQVP 2380 DGPPDLLLES 2390 QWHHYSGEAS 2400 SSEEEPPSPD 2410 DKENQAPKRT 2420 GPHLRFEISS 2430 EDGFSVEAES 2440 LEGAWRTLIE 2450 KVQEARGHAR 2460 LRHLSFSGMS 2470 GARLLGIHHD 2480 AVIFLAEQLP 2490 GAQRCQHYKF 2500 RYHQQGEGQE 2510 EPPLNPHGAA 2520 RAEVYLRKCT 2530 FDMFNFLASQ 2540 HRVLPEGATC 2550 DEEEDEVQLR 2560 STRRATSLEL 2570 PMAMRFRHLK 2580 KTSKEAVGVY 2590 RSAIHGRGLF 2600 CKRNIDAGEM 2610 VIEYSGIVIR 2620 SVLTDKREKF 2630 YDGKGIGCYM 2640 FRMDDFDVVD 2650 ATMHGNAARF 2660 INHSCEPNCF 2670 SRVIHVEGQK 2680 HIVIFALRRI 2690 LRGEELTYDY 2700 KFPIEDASNK 2710 LPCNCGAKRC RRFLN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035097 histone methyltransferase complex
Cellular Component GO:0044665 MLL1/2 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042800 histone H3K4 methyltransferase activity
Molecular Function GO:0140945 histone H3K4 monomethyltransferase activity
Molecular Function GO:0045322 unmethylated CpG binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032259 methylation
Biological Process GO:0045893 positive regulation of DNA-templated transcription

Reference

PMID: N/A