Search Results
Overview
| Uniprot ID | Q9UMR3 |
|---|---|
| Protein Name | T-box transcription factor TBX20 |
| Gene Name | TBX20 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 205 | KQMVSFEKVKLTNNE |
Function
Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart
Protein Sequence
10
MEFTASPKPQ
20
LSSRANAFSI
30
AALMSSGGSK
40
EKEATENTIK
50
PLEQFVEKSS
60
CAQPLGELTS
70
LDAHGEFGGG
80
SGSSPSSSSL
90
CTEPLIPTTP
100
IIPSEEMAKI
110
ACSLETKELW
120
DKFHELGTEM
130
IITKSGRRMF
140
PTIRVSFSGV
150
DPEAKYIVLM
160
DIVPVDNKRY
170
RYAYHRSSWL
180
VAGKADPPLP
190
ARLYVHPDSP
200
FTGEQLLKQM
210
VSFEKVKLTN
220
NELDQHGHII
230
LNSMHKYQPR
240
VHIIKKKDHT
250
ASLLNLKSEE
260
FRTFIFPETV
270
FTAVTAYQNQ
280
LITKLKIDSN
290
PFAKGFRDSS
300
RLTDIERESV
310
ESLIQKHSYA
320
RSPIRTYGGE
330
EDVLGDESQT
340
TPNRGSAFTT
350
SDNLSLSSWV
360
SSSSSFPGFQ
370
HPQSLTALGT
380
STASIATPIP
390
HPIQGSLPPY
400
SRLGMPLTPS
410
AIASSMQGSG
420
PTFPSFHMPR
430
YHHYFQQGPY
440
AAIQGLRHSS
AVMTPFV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0003180 | aortic valve morphogenesis |
| Biological Process | GO:0060413 | atrial septum morphogenesis |
| Biological Process | GO:0036302 | atrioventricular canal development |
| Biological Process | GO:0003171 | atrioventricular valve development |
| Biological Process | GO:0003207 | cardiac chamber formation |
| Biological Process | GO:0055008 | cardiac muscle tissue morphogenesis |
| Biological Process | GO:0003215 | cardiac right ventricle morphogenesis |
| Biological Process | GO:0003279 | cardiac septum development |
| Biological Process | GO:0001708 | cell fate specification |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0009953 | dorsal/ventral pattern formation |
| Biological Process | GO:0036306 | embryonic heart tube elongation |
| Biological Process | GO:0003143 | embryonic heart tube morphogenesis |
| Biological Process | GO:0003272 | endocardial cushion formation |
| Biological Process | GO:0003203 | endocardial cushion morphogenesis |
| Biological Process | GO:0001706 | endoderm formation |
| Biological Process | GO:0035922 | foramen ovale closure |
| Biological Process | GO:0001947 | heart looping |
| Biological Process | GO:0048370 | lateral mesoderm formation |
| Biological Process | GO:0014031 | mesenchymal cell development |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0003148 | outflow tract septum morphogenesis |
| Biological Process | GO:0003344 | pericardium morphogenesis |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0030513 | positive regulation of BMP signaling pathway |
| Biological Process | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| Biological Process | GO:0090068 | positive regulation of cell cycle process |
| Biological Process | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0003193 | pulmonary valve formation |
| Biological Process | GO:0060577 | pulmonary vein morphogenesis |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0003175 | tricuspid valve development |
| Biological Process | GO:0021524 | visceral motor neuron differentiation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.