Overview
| Uniprot ID | Q9UMX0 |
|---|
| Protein Name | Ubiquilin-1 |
|---|
| Gene Name | UBQLN1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 47 |
TVKTPKEKEEFAVPE |
Function
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804)
Protein Sequence
10
MAESGESGGP
20
PGSQDSAAGA
30
EGAGAPAAAA
40
SAEPKIMKVT
50
VKTPKEKEEF
60
AVPENSSVQQ
70
FKEEISKRFK
80
SHTDQLVLIF
90
AGKILKDQDT
100
LSQHGIHDGL
110
TVHLVIKTQN
120
RPQDHSAQQT
130
NTAGSNVTTS
140
STPNSNSTSG
150
SATSNPFGLG
160
GLGGLAGLSS
170
LGLNTTNFSE
180
LQSQMQRQLL
190
SNPEMMVQIM
200
ENPFVQSMLS
210
NPDLMRQLIM
220
ANPQMQQLIQ
230
RNPEISHMLN
240
NPDIMRQTLE
250
LARNPAMMQE
260
MMRNQDRALS
270
NLESIPGGYN
280
ALRRMYTDIQ
290
EPMLSAAQEQ
300
FGGNPFASLV
310
SNTSSGEGSQ
320
PSRTENRDPL
330
PNPWAPQTSQ
340
SSSASSGTAS
350
TVGGTTGSTA
360
SGTSGQSTTA
370
PNLVPGVGAS
380
MFNTPGMQSL
390
LQQITENPQL
400
MQNMLSAPYM
410
RSMMQSLSQN
420
PDLAAQMMLN
430
NPLFAGNPQL
440
QEQMRQQLPT
450
FLQQMQNPDT
460
LSAMSNPRAM
470
QALLQIQQGL
480
QTLATEAPGL
490
IPGFTPGLGA
500
LGSTGGSSGT
510
NGSNATPSEN
520
TSPTAGTTEP
530
GHQQFIQQML
540
QALAGVNPQL
550
QNPEVRFQQQ
560
LEQLSAMGFL
570
NREANLQALI
580
ATGGDINAAI
ERLLGSQPS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016235 |
aggresome |
| Cellular Component |
GO:0005776 |
autophagosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019900 |
kinase binding |
| Molecular Function |
GO:0031593 |
polyubiquitin modification-dependent protein binding |
| Biological Process |
GO:0035973 |
aggrephagy |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0097352 |
autophagosome maturation |
| Biological Process |
GO:0071456 |
cellular response to hypoxia |
| Biological Process |
GO:0036503 |
ERAD pathway |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:1901340 |
negative regulation of store-operated calcium channel activity |
| Biological Process |
GO:0034140 |
negative regulation of toll-like receptor 3 signaling pathway |
| Biological Process |
GO:1904294 |
positive regulation of ERAD pathway |
| Biological Process |
GO:0031398 |
positive regulation of protein ubiquitination |
| Biological Process |
GO:0016241 |
regulation of macroautophagy |
| Biological Process |
GO:1902175 |
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process |
GO:0031396 |
regulation of protein ubiquitination |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.