Overview
| Uniprot ID | Q9UMX2 |
|---|
| Protein Name | Ornithine decarboxylase antizyme 3 |
|---|
| Gene Name | OAZ3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 60 |
CYKSITYKEEEDLTL |
Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity)
Protein Sequence
10
MPCKRCRPSV
20
YSLSYIKRGK
30
TRNYLYPIWS
40
PYAYYLYCYK
50
YRITLREKML
60
PRCYKSITYK
70
EEEDLTLQPR
80
SCLQCSESLV
90
GLQEGKSTEQ
100
GNHDQLKELY
110
SAGNLTVLAT
120
DPLLHQDPVQ
130
LDFHFRLTSQ
140
TSAHWHGLLC
150
DRRLFLDIPY
160
QALDQGNRES
170
LTATLEYVEE
180
KTNVDSVFVN
190
FQNDRNDRGA
200
LLRAFSYMGF
210
EVVRPDHPAL
220
PPLDNVIFMV
230
YPLERDVGHL
PSEPP
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0008073 |
ornithine decarboxylase inhibitor activity |
| Biological Process |
GO:1902268 |
negative regulation of polyamine transmembrane transport |
| Biological Process |
GO:0051497 |
negative regulation of stress fiber assembly |
| Biological Process |
GO:0006596 |
polyamine biosynthetic process |
| Biological Process |
GO:0090316 |
positive regulation of intracellular protein transport |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Cellular Component |
GO:0072562 |
blood microparticle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0036126 |
sperm flagellum |
| Molecular Function |
GO:0071532 |
ankyrin repeat binding |
| Biological Process |
GO:0090368 |
regulation of ornithine metabolic process |
| Biological Process |
GO:0007283 |
spermatogenesis |
| Biological Process |
GO:0075523 |
viral translational frameshifting |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.