Search Results

Overview

Uniprot ID	Q9UMY1
Protein Name	U3 small nucleolar RNA-associated protein NOL7
Gene Name	NOL7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
112	FIEQKKRKLLPDTIL
131	TASQTNIKKSPGKVK
162	SKKVKVQKVQSVSQN
170	VQSVSQNKSYLAVRL
210	TNRTTVNKFLSLANK

Function

Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:34516797, PubMed:37246770). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA (PubMed:37246770). Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability (PubMed:37246770)

Protein Sequence

10 MVQLRPRASR 20 APASAEAMVD 30 EGQLASEEEE 40 AEHGLLLGQP 50 SSGAAAEPLE 60 EDEEGDDEFD 70 DEAPEELTFA 80 SAQAEAREEE 90 RRVRETVRRD 100 KTLLKEKRKR 110 REELFIEQKK 120 RKLLPDTILE 130 KLTTASQTNI 140 KKSPGKVKEV 150 NLQKKNEDCE 160 KGNDSKKVKV 170 QKVQSVSQNK 180 SYLAVRLKDQ 190 DLRDSRQQAA 200 QAFIHNSLYG 210 PGTNRTTVNK 220 FLSLANKRLP 230 VKRAAVQFLN 240 NAWGIQKKQN 250 AKRFKRRWMV RKMKTKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0032040	small-subunit processome
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0030490	maturation of SSU-rRNA
Biological Process	GO:0042274	ribosomal small subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.