Search Results

Overview

Uniprot ID	Q9UMY4
Protein Name	Sorting nexin-12
Gene Name	SNX12
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
87	NELERDSKIVVPPLP

Function

May be involved in several stages of intracellular trafficking

Protein Sequence

10 MSDTAVADTR 20 RLNSKPQDLT 30 DAYGPPSNFL 40 EIDIFNPQTV 50 GVGRARFTTY 60 EVRMRTNLPI 70 FKLKESCVRR 80 RYSDFEWLKN 90 ELERDSKIVV 100 PPLPGKALKR 110 QLPFRGDEGI 120 FEESFIEERR 130 QGLEQFINKI 140 AGHPLAQNER 150 CLHMFLQEEA 160 IDRNYVPGKV RQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0030904	retromer complex
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding
Biological Process	GO:0032456	endocytic recycling
Biological Process	GO:0034499	late endosome to Golgi transport
Biological Process	GO:2000642	negative regulation of early endosome to late endosome transport
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0042177	negative regulation of protein catabolic process
Biological Process	GO:0010955	negative regulation of protein processing
Biological Process	GO:0051224	negative regulation of protein transport
Biological Process	GO:0015031	protein transport
Biological Process	GO:0030100	regulation of endocytosis

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.