Search Results
Overview
| Uniprot ID | Q9UN81 |
|---|---|
| Protein Name | LINE-1 retrotransposable element ORF1 protein |
| Gene Name | L1RE1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 94 | LKELMELKTKARELR |
Function
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded
Protein Sequence
10
MGKKQNRKTG
20
NSKTQSASPP
30
PKERSSSPAT
40
EQSWMENDFD
50
ELREEGFRRS
60
NYSELREDIQ
70
TKGKEVENFE
80
KNLEECITRI
90
TNTEKCLKEL
100
MELKTKAREL
110
REECRSLRSR
120
CDQLEERVSA
130
MEDEMNEMKR
140
EGKFREKRIK
150
RNEQSLQEIW
160
DYVKRPNLRL
170
IGVPESDVEN
180
GTKLENTLQD
190
IIQENFPNLA
200
RQANVQIQEI
210
QRTPQRYSSR
220
RATPRHIIVR
230
FTKVEMKEKM
240
LRAAREKGRV
250
TLKGKPIRLT
260
ADLSAETLQA
270
RREWGPIFNI
280
LKEKNFQPRI
290
SYPAKLSFIS
300
EGEIKYFIDK
310
QMLRDFVTTR
320
PALKELLKEA
330
LNMERNNRYQ
PLQNHAKM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0003727 | single-stranded RNA binding |
| Biological Process | GO:0032197 | retrotransposition |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.