Search Results

Overview

Uniprot IDQ9UNA0
Protein NameA disintegrin and metalloproteinase with thrombospondin motifs 5
Gene NameADAMTS5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
715 CDGIIGSKLQYDKCG

Function

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection

Protein Sequence

10 MLLGWASLLL 20 CAFRLPLAAV 30 GPAATPAQDK 40 AGQPPTAAAA 50 AQPRRRQGEE 60 VQERAEPPGH 70 PHPLAQRRRS 80 KGLVQNIDQL 90 YSGGGKVGYL 100 VYAGGRRFLL 110 DLERDGSVGI 120 AGFVPAGGGT 130 SAPWRHRSHC 140 FYRGTVDGSP 150 RSLAVFDLCG 160 GLDGFFAVKH 170 ARYTLKPLLR 180 GPWAEEEKGR 190 VYGDGSARIL 200 HVYTREGFSF 210 EALPPRASCE 220 TPASTPEAHE 230 HAPAHSNPSG 240 RAALASQLLD 250 QSALSPAGGS 260 GPQTWWRRRR 270 RSISRARQVE 280 LLLVADASMA 290 RLYGRGLQHY 300 LLTLASIANR 310 LYSHASIENH 320 IRLAVVKVVV 330 LGDKDKSLEV 340 SKNAATTLKN 350 FCKWQHQHNQ 360 LGDDHEEHYD 370 AAILFTREDL 380 CGHHSCDTLG 390 MADVGTICSP 400 ERSCAVIEDD 410 GLHAAFTVAH 420 EIGHLLGLSH 430 DDSKFCEETF 440 GSTEDKRLMS 450 SILTSIDASK 460 PWSKCTSATI 470 TEFLDDGHGN 480 CLLDLPRKQI 490 LGPEELPGQT 500 YDATQQCNLT 510 FGPEYSVCPG 520 MDVCARLWCA 530 VVRQGQMVCL 540 TKKLPAVEGT 550 PCGKGRICLQ 560 GKCVDKTKKK 570 YYSTSSHGNW 580 GSWGSWGQCS 590 RSCGGGVQFA 600 YRHCNNPAPR 610 NNGRYCTGKR 620 AIYRSCSLMP 630 CPPNGKSFRH 640 EQCEAKNGYQ 650 SDAKGVKTFV 660 EWVPKYAGVL 670 PADVCKLTCR 680 AKGTGYYVVF 690 SPKVTDGTEC 700 RLYSNSVCVR 710 GKCVRTGCDG 720 IIGSKLQYDK 730 CGVCGGDNSS 740 CTKIVGTFNK 750 KSKGYTDVVR 760 IPEGATHIKV 770 RQFKAKDQTR 780 FTAYLALKKK 790 NGEYLINGKY 800 MISTSETIID 810 INGTVMNYSG 820 WSHRDDFLHG 830 MGYSATKEIL 840 IVQILATDPT 850 KPLDVRYSFF 860 VPKKSTPKVN 870 SVTSHGSNKV 880 GSHTSQPQWV 890 TGPWLACSRT 900 CDTGWHTRTV 910 QCQDGNRKLA 920 KGCPLSQRPS 930 AFKQCLLKKC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0004175 endopeptidase activity
Molecular Function GO:0050840 extracellular matrix binding
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0004222 metalloendopeptidase activity
Molecular Function GO:0008237 metallopeptidase activity
Molecular Function GO:0008233 peptidase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0003180 aortic valve morphogenesis
Biological Process GO:0003203 endocardial cushion morphogenesis
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0007520 myoblast fusion
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0006508 proteolysis
Biological Process GO:0003184 pulmonary valve morphogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.