Overview
| Uniprot ID | Q9UNF0 |
|---|
| Protein Name | Protein kinase C and casein kinase substrate in neurons protein 2 |
|---|
| Gene Name | PACSIN2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 177 |
ISREANSKADPSLNP |
| 383 |
EKDDTKAKNVSSYEK |
| 53 |
HERARIEKAYAQQLT |
Function
Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity)
Protein Sequence
10
MSVTYDDSVG
20
VEVSSDSFWE
30
VGNYKRTVKR
40
IDDGHRLCSD
50
LMNCLHERAR
60
IEKAYAQQLT
70
EWARRWRQLV
80
EKGPQYGTVE
90
KAWMAFMSEA
100
ERVSELHLEV
110
KASLMNDDFE
120
KIKNWQKEAF
130
HKQMMGGFKE
140
TKEAEDGFRK
150
AQKPWAKKLK
160
EVEAAKKAHH
170
AACKEEKLAI
180
SREANSKADP
190
SLNPEQLKKL
200
QDKIEKCKQD
210
VLKTKEKYEK
220
SLKELDQGTP
230
QYMENMEQVF
240
EQCQQFEEKR
250
LRFFREVLLE
260
VQKHLDLSNV
270
AGYKAIYHDL
280
EQSIRAADAV
290
EDLRWFRANH
300
GPGMAMNWPQ
310
FEEWSADLNR
320
TLSRREKKKA
330
TDGVTLTGIN
340
QTGDQSLPSK
350
PSSTLNVPSN
360
PAQSAQSQSS
370
YNPFEDEDDT
380
GSTVSEKDDT
390
KAKNVSSYEK
400
TQSYPTDWSD
410
DESNNPFSST
420
DANGDSNPFD
430
DDATSGTEVR
440
VRALYDYEGQ
450
EHDELSFKAG
460
DELTKMEDED
470
EQGWCKGRLD
480
NGQVGLYPAN
YVEAIQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0005901 |
caveola |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0070300 |
phosphatidic acid binding |
| Molecular Function |
GO:0005543 |
phospholipid binding |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0070836 |
caveola assembly |
| Biological Process |
GO:0072584 |
caveolin-mediated endocytosis |
| Biological Process |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
| Biological Process |
GO:0048858 |
cell projection morphogenesis |
| Biological Process |
GO:0007010 |
cytoskeleton organization |
| Biological Process |
GO:0050804 |
modulation of chemical synaptic transmission |
| Biological Process |
GO:0097320 |
plasma membrane tubulation |
| Biological Process |
GO:0036010 |
protein localization to endosome |
| Biological Process |
GO:0030100 |
regulation of endocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.