Search Results

Overview

Uniprot IDQ9UNF1
Protein NameMelanoma-associated antigen D2
Gene NameMAGED2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
133 VSHVADTKVNTKAQE
207 TGGRRVSKALMASMA
261 KARRRAAKLQSSQEP
47 PETPKASKALEVSED
59 SEDVKVSKASGVSKA
65 SKASGVSKATEVSKT
71 SKATEVSKTPEAREA

Function

Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule

Protein Sequence

10 MSDTSESGAG 20 LTRFQAEASE 30 KDSSSMMQTL 40 LTVTQNVEVP 50 ETPKASKALE 60 VSEDVKVSKA 70 SGVSKATEVS 80 KTPEAREAPA 90 TQASSTTQLT 100 DTQVLAAENK 110 SLAADTKKQN 120 ADPQAVTMPA 130 TETKKVSHVA 140 DTKVNTKAQE 150 TEAAPSQAPA 160 DEPEPESAAA 170 QSQENQDTRP 180 KVKAKKARKV 190 KHLDGEEDGS 200 SDQSQASGTT 210 GGRRVSKALM 220 ASMARRASRG 230 PIAFWARRAS 240 RTRLAAWARR 250 ALLSLRSPKA 260 RRGKARRRAA 270 KLQSSQEPEA 280 PPPRDVALLQ 290 GRANDLVKYL 300 LAKDQTKIPI 310 KRSDMLKDII 320 KEYTDVYPEI 330 IERAGYSLEK 340 VFGIQLKEID 350 KNDHLYILLS 360 TLEPTDAGIL 370 GTTKDSPKLG 380 LLMVLLSIIF 390 MNGNRSSEAV 400 IWEVLRKLGL 410 RPGIHHSLFG 420 DVKKLITDEF 430 VKQKYLDYAR 440 VPNSNPPEYE 450 FFWGLRSYYE 460 TSKMKVLKFA 470 CKVQKKDPKE 480 WAAQYREAME 490 ADLKAAAEAA 500 AEAKARAEIR 510 ARMGIGLGSE 520 NAAGPCNWDE 530 ADIGPWAKAR 540 IQAGAEAKAK 550 AQESGSASTG 560 ASTSTNNSAS 570 ASASTSGGFS 580 AGASLTATLT 590 FGLFAGLGGA 600 GASTSGSSGA CGFSYK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0070294 renal sodium ion absorption
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031093 platelet alpha granule lumen
Biological Process GO:0007565 female pregnancy

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.