Search Results

Overview

Uniprot IDQ9UNH7
Protein NameSorting nexin-6
Gene NameSNX6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
139 EYLAIFKKTVAMHEV
183 RGKNKKEKLEDFFKN
193 DFFKNMVKSADGVIV

Function

Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable)

Protein Sequence

10 MMEGLDDGPD 20 FLSEEDRGLK 30 AINVDLQSDA 40 ALQVDISDAL 50 SERDKVKFTV 60 HTKSSLPNFK 70 QNEFSVVRQH 80 EEFIWLHDSF 90 VENEDYAGYI 100 IPPAPPRPDF 110 DASREKLQKL 120 GEGEGSMTKE 130 EFTKMKQELE 140 AEYLAIFKKT 150 VAMHEVFLCR 160 VAAHPILRRD 170 LNFHVFLEYN 180 QDLSVRGKNK 190 KEKLEDFFKN 200 MVKSADGVIV 210 SGVKDVDDFF 220 EHERTFLLEY 230 HNRVKDASAK 240 SDRMTRSHKS 250 AADDYNRIGS 260 SLYALGTQDS 270 TDICKFFLKV 280 SELFDKTRKI 290 EARVSADEDL 300 KLSDLLKYYL 310 RESQAAKDLL 320 YRRSRSLVDY 330 ENANKALDKA 340 RAKNKDVLQA 350 ETSQQLCCQK 360 FEKISESAKQ 370 ELIDFKTRRV 380 AAFRKNLVEL 390 AELELKHAKG 400 NLQLLQNCLA VLNGDT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098842 postsynaptic early endosome
Cellular Component GO:0030904 retromer complex
Cellular Component GO:0030905 retromer, tubulation complex
Cellular Component GO:0097422 tubular endosome
Molecular Function GO:0034452 dynactin binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0034713 type I transforming growth factor beta receptor binding
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.