Overview
| Uniprot ID | Q9UNP4 |
|---|
| Protein Name | Lactosylceramide alpha-2,3-sialyltransferase |
|---|
| Gene Name | ST3GAL5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 147 |
DLLPFVQKAPKDSEA |
Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) (PubMed:16934889, PubMed:9822625). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer) (PubMed:16934889)
Protein Sequence
10
MRTKAAGCAE
20
RRPLQPRTEA
30
AAAPAGRAMP
40
SEYTYVKLRS
50
DCSRPSLQWY
60
TRAQSKMRRP
70
SLLLKDILKC
80
TLLVFGVWIL
90
YILKLNYTTE
100
ECDMKKMHYV
110
DPDHVKRAQK
120
YAQQVLQKEC
130
RPKFAKTSMA
140
LLFEHRYSVD
150
LLPFVQKAPK
160
DSEAESKYDP
170
PFGFRKFSSK
180
VQTLLELLPE
190
HDLPEHLKAK
200
TCRRCVVIGS
210
GGILHGLELG
220
HTLNQFDVVI
230
RLNSAPVEGY
240
SEHVGNKTTI
250
RMTYPEGAPL
260
SDLEYYSNDL
270
FVAVLFKSVD
280
FNWLQAMVKK
290
ETLPFWVRLF
300
FWKQVAEKIP
310
LQPKHFRILN
320
PVIIKETAFD
330
ILQYSEPQSR
340
FWGRDKNVPT
350
IGVIAVVLAT
360
HLCDEVSLAG
370
FGYDLNQPRT
380
PLHYFDSQCM
390
AAMNFQTMHN
400
VTTETKFLLK
410
LVKEGVVKDL
SGGIDREF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| Molecular Function |
GO:0047291 |
lactosylceramide alpha-2,3-sialyltransferase activity |
| Molecular Function |
GO:0008373 |
sialyltransferase activity |
| Biological Process |
GO:0001574 |
ganglioside biosynthetic process |
| Biological Process |
GO:0009101 |
glycoprotein biosynthetic process |
| Biological Process |
GO:0006688 |
glycosphingolipid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.