Overview
| Uniprot ID | Q9UNQ2 |
|---|
| Protein Name | Dimethyladenosine transferase |
|---|
| Gene Name | DIMT1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 5 |
***MPKVKSGAIGRR |
Function
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)
Protein Sequence
10
MPKVKSGAIG
20
RRRGRQEQRR
30
ELKSAGGLMF
40
NTGIGQHILK
50
NPLIINSIID
60
KAALRPTDVV
70
LEVGPGTGNM
80
TVKLLEKAKK
90
VVACELDPRL
100
VAELHKRVQG
110
TPVASKLQVL
120
VGDVLKTDLP
130
FFDTCVANLP
140
YQISSPFVFK
150
LLLHRPFFRC
160
AILMFQREFA
170
LRLVAKPGDK
180
LYCRLSINTQ
190
LLARVDHLMK
200
VGKNNFRPPP
210
KVESSVVRIE
220
PKNPPPPINF
230
QEWDGLVRIT
240
FVRKNKTLSA
250
AFKSSAVQQL
260
LEKNYRIHCS
270
VHNIIIPEDF
280
SIADKIQQIL
290
TSTGFSDKRA
300
RSMDIDDFIR
310
LLHGFNAEGI
HFS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0052909 |
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000179 |
rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| Biological Process |
GO:2000234 |
positive regulation of rRNA processing |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0031167 |
rRNA methylation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.