Search Results

Overview

Uniprot ID	Q9UNY4
Protein Name	Transcription termination factor 2
Gene Name	TTF2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
283	QKGGPLNKEYTNWEA
404	PASGVSKKVEPSDPV

Function

DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing

Protein Sequence

10 MEEVRCPEHG 20 TFCFLKTGVR 30 DGPNKGKSFY 40 VCRADTCSFV 50 RATDIPVSHC 60 LLHEDFVVEL 70 QGLLLPQDKK 80 EYRLFFRCIR 90 SKAEGKRWCG 100 SIPWQDPDSK 110 EHSVSNKSQH 120 ASETFHHSSN 130 WLRNPFKVLD 140 KNQEPALWKQ 150 LIKGEGEEKK 160 ADKKQREKGD 170 QLFDQKKEQK 180 PEMMEKDLSS 190 GLVPKKKQSV 200 VQEKKQEEGA 210 EIQCEAETGG 220 THKRDFSEIK 230 SQQCQGNELT 240 RPSASSQEKS 250 SGKSQDVQRE 260 SEPLREKVTQ 270 LLPQNVHSHN 280 SISKPQKGGP 290 LNKEYTNWEA 300 KETKAKDGPS 310 IQATQKSLPQ 320 GHFQERPETH 330 SVPAPGGPAA 340 QAAPAAPGLS 350 LGEGREAATS 360 SDDEEEDDVV 370 FVSSKPGSPL 380 LFDSTLDLET 390 KENLQFPDRS 400 VQRKVSPASG 410 VSKKVEPSDP 420 VARRVYLTTQ 430 LKQKKSTLAS 440 VNIQALPDKG 450 QKLIKQIQEL 460 EEVLSGLTLS 470 PEQGTNEKSN 480 SQVPQQSHFT 490 KTTTGPPHLV 500 PPQPLPRRGT 510 QPVGSLELKS 520 ACQVTAGGSS 530 QCYRGHTNQD 540 HVHAVWKITS 550 EAIGQLHRSL 560 ESCPGETVVA 570 EDPAGLKVPL 580 LLHQKQALAW 590 LLWRESQKPQ 600 GGILADDMGL 610 GKTLTMIALI 620 LTQKNQEKKE 630 EKEKSTALTW 640 LSKDDSCDFT 650 SHGTLIICPA 660 SLIHHWKNEV 670 EKRVNSNKLR 680 VYLYHGPNRD 690 SRARVLSTYD 700 IVITTYSLVA 710 KEIPTNKQEA 720 EIPGANLNVE 730 GTSTPLLRIA 740 WARIILDEAH 750 NVKNPRVQTS 760 IAVCKLQACA 770 RWAVTGTPIQ 780 NNLLDMYSLL 790 KFLRCSPFDE 800 FNLWRSQVDN 810 GSKKGGERLS 820 ILTKSLLLRR 830 TKDQLDSTGR 840 PLVILPQRKF 850 QLHHLKLSED 860 EETVYNVFFA 870 RSRSALQSYL 880 KRHESRGNQS 890 GRSPNNPFSR 900 VALEFGSEEP 910 RHSEAADSPR 920 SSTVHILSQL 930 LRLRQCCCHL 940 SLLKSALDPM 950 ELKGEGLVLS 960 LEEQLSALTL 970 SELRDSEPSS 980 TVSLNGTFFK 990 MELFEGMRES 1000 TKISSLLAEL 1010 EAIQRNSASQ 1020 KSVIVSQWTN 1030 MLKVVALHLK 1040 KHGLTYATID 1050 GSVNPKQRMD 1060 LVEAFNHSRG 1070 PQVMLISLLA 1080 GGVGLNLTGG 1090 NHLFLLDMHW 1100 NPSLEDQACD 1110 RIYRVGQQKD 1120 VVIHRFVCEG 1130 TVEEKILQLQ 1140 EKKKDLAKQV 1150 LSGSGESVTK 1160 LTLADLRVLF GI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005681	spliceosomal complex
Cellular Component	GO:0008023	transcription elongation factor complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0006353	DNA-templated transcription termination
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0008380	RNA splicing
Biological Process	GO:0006369	termination of RNA polymerase II transcription

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.