Search Results

Overview

Uniprot IDQ9UPA5
Protein NameProtein bassoon
Gene NameBSN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1695 SLAVEARKYGLALDP
3371 GMEQKISKFSPIEEA
615 KKTRVPTKAEPMPKP

Function

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity)

Protein Sequence

10 MGNEVSLEGG 20 AGDGPLPPGG 30 AGPGPGPGPG 40 PGAGKPPSAP 50 AGGGQLPAAG 60 AARSTAVPPV 70 PGPGPGPGPG 80 PGPGSTSRRL 90 DPKEPLGNQR 100 AASPTPKQAS 110 ATTPGHESPR 120 ETRAQGPAGQ 130 EADGPRRTLQ 140 VDSRTQRSGR 150 SPSVSPDRGS 160 TPTSPYSVPQ 170 IAPLPSSTLC 180 PICKTSDLTS 190 TPSQPNFNTC 200 TQCHNKVCNQ 210 CGFNPNPHLT 220 QVKEWLCLNC 230 QMQRALGMDM 240 TTAPRSKSQQ 250 QLHSPALSPA 260 HSPAKQPLGK 270 PDQERSRGPG 280 GPQPGSRQAE 290 TARATSVPGP 300 AQAAAPPEVG 310 RVSPQPPQPT 320 KPSTAEPRPP 330 AGEAPAKSAT 340 AVPAGLGATE 350 QTQEGLTGKL 360 FGLGASLLTQ 370 ASTLMSVQPE 380 ADTQGQPAPS 390 KGTPKIVFND 400 ASKEAGPKPL 410 GSGPGPGPAP 420 GAKTEPGARM 430 GPGSGPGALP 440 KTGGTTSPKH 450 GRAEHQAASK 460 AAAKPKTMPK 470 ERAICPLCQA 480 ELNVGSKSPA 490 NYNTCTTCRL 500 QVCNLCGFNP 510 TPHLVEKTEW 520 LCLNCQTKRL 530 LEGSLGEPTP 540 LPPPTSQQPP 550 VGAPHRASGT 560 SPLKQKGPQG 570 LGQPSGPLPA 580 KASPLSTKAS 590 PLPSKASPQA 600 KPLRASEPSK 610 TPSSVQEKKT 620 RVPTKAEPMP 630 KPPPETTPTP 640 ATPKVKSGVR 650 RAEPATPVVK 660 AVPEAPKGGE 670 AEDLVGKPYS 680 QDASRSPQSL 690 SDTGYSSDGI 700 SSSQSEITGV 710 VQQEVEQLDS 720 AGVTGPHPPS 730 PSEIHKVGSS 740 MRPLLQAQGL 750 APSERSKPLS 760 SGTGEEQKQR 770 PHSLSITPEA 780 FDSDEELEDI 790 LEEDEDSAEW 800 RRRREQQDTA 810 ESSDDFGSQL 820 RHDYVEDSSE 830 GGLSPLPPQP 840 PARAAELTDE 850 DFMRRQILEM 860 SAEEDNLEED 870 DTATSGRGLA 880 KHGTQKGGPR 890 PRPEPSQEPA 900 ALPKRRLPHN 910 ATTGYEELLP 920 EGGSAEATDG 930 SGTLQGGLRR 940 FKTIELNSTG 950 SYGHELDLGQ 960 GPDPSLDREP 970 ELEMESLTGS 980 PEDRSRGEHS 990 STLPASTPSY 1000 TSGTSPTSLS 1010 SLEEDSDSSP 1020 SRRQRLEEAK 1030 QQRKARHRSH 1040 GPLLPTIEDS 1050 SEEEELREEE 1060 ELLREQEKMR 1070 EVEQQRIRST 1080 ARKTRRDKEE 1090 LRAQRRRERS 1100 KTPPSNLSPI 1110 EDASPTEELR 1120 QAAEMEELHR 1130 SSCSEYSPSP 1140 SLDSEAEALD 1150 GGPSRLYKSG 1160 SEYNLPTFMS 1170 LYSPTETPSG 1180 SSTTPSSGRP 1190 LKSAEEAYEE 1200 MMRKAELLQR 1210 QQGQAAGARG 1220 PHGGPSQPTG 1230 PRGLGSFEYQ 1240 DTTDREYGQA 1250 AQPAAEGTPA 1260 SLGAAVYEEI 1270 LQTSQSIVRM 1280 RQASSRDLAF 1290 AEDKKKEKQF 1300 LNAESAYMDP 1310 MKQNGGPLTP 1320 GTSPTQLAAP 1330 VSFSTPTSSD 1340 SSGGRVIPDV 1350 RVTQHFAKET 1360 QDPLKLHSSP 1370 ASPSSASKEI 1380 GMPFSQGPGT 1390 PATTAVAPCP 1400 AGLPRGYMTP 1410 ASPAGSERSP 1420 SPSSTAHSYG 1430 HSPTTANYGS 1440 QTEDLPQAPS 1450 GLAAAGRAAR 1460 EKPLSASDGE 1470 GGTPQPSRAY 1480 SYFASSSPPL 1490 SPSSPSESPT 1500 FSPGKMGPRA 1510 TAEFSTQTPS 1520 PAPASDMPRS 1530 PGAPTPSPMV 1540 AQGTQTPHRP 1550 STPRLVWQES 1560 SQEAPFMVIT 1570 LASDASSQTR 1580 MVHASASTSP 1590 LCSPTETQPT 1600 THGYSQTTPP 1610 SVSQLPPEPP 1620 GPPGFPRVPS 1630 AGADGPLALY 1640 GWGALPAENI 1650 SLCRISSVPG 1660 TSRVEPGPRT 1670 PGTAVVDLRT 1680 AVKPTPIILT 1690 DQGMDLTSLA 1700 VEARKYGLAL 1710 DPIPGRQSTA 1720 VQPLVINLNA 1730 QEHTFLATAT 1740 TVSITMASSV 1750 FMAQQKQPVV 1760 YGDPYQSRLD 1770 FGQGGGSPVC 1780 LAQVKQVEQA 1790 VQTAPYRSGP 1800 RGRPREAKFA 1810 RYNLPNQVAP 1820 LARRDVLITQ 1830 MGTAQSIGLK 1840 PGPVPEPGAE 1850 PHRATPAELR 1860 SHALPGARKP 1870 HTVVVQMGEG 1880 TAGTVTTLLP 1890 EEPAGALDLT 1900 GMRPESQLAC 1910 CDMVYKLPFG 1920 SSCTGTFHPA 1930 PSVPEKSMAD 1940 AAPPGQSSSP 1950 FYGPRDPEPP 1960 EPPTYRAQGV 1970 VGPGPHEEQR 1980 PYPQGLPGRL 1990 YSSMSDTNLA 2000 EAGLNYHAQR 2010 IGQLFQGPGR 2020 DSAMDLSSLK 2030 HSYSLGFADG 2040 RYLGQGLQYG 2050 SVTDLRHPTD 2060 LLAHPLPMRR 2070 YSSVSNIYSD 2080 HRYGPRGDAV 2090 GFQEASLAQY 2100 SATTAREISR 2110 MCAALNSMDQ 2120 YGGRHGSGGG 2130 GPDLVQYQPQ 2140 HGPGLSAPQS 2150 LVPLRPGLLG 2160 NPTFPEGHPS 2170 PGNLAQYGPA 2180 AGQGTAVRQL 2190 LPSTATVRAA 2200 DGMIYSTINT 2210 PIAATLPITT 2220 QPASVLRPMV 2230 RGGMYRPYAS 2240 GGITAVPLTS 2250 LTRVPMIAPR 2260 VPLGPTGLYR 2270 YPAPSRFPIA 2280 SSVPPAEGPV 2290 YLGKPAAAKA 2300 PGAGGPSRPE 2310 MPVGAAREEP 2320 LPTTTPAAIK 2330 EAAGAPAPAP 2340 LAGQKPPADA 2350 APGGGSGALS 2360 RPGFEKEEAS 2370 QEERQRKQQE 2380 QLLQLERERV 2390 ELEKLRQLRL 2400 QEELERERVE 2410 LQRHREEEQL 2420 LVQRELQELQ 2430 TIKHHVLQQQ 2440 QEERQAQFAL 2450 QREQLAQQRL 2460 QLEQIQQLQQ 2470 QLQQQLEEQK 2480 QRQKAPFPAA 2490 CEAPGRGPPL 2500 AAAELAQNGQ 2510 YWPPLTHAAF 2520 IAMAGPEGLG 2530 QPREPVLHRG 2540 LPSSASDMSL 2550 QTEEQWEASR 2560 SGIKKRHSMP 2570 RLRDACELES 2580 GTEPCVVRRI 2590 ADSSVQTDDE 2600 DGESRYLLSR 2610 RRRARRSADC 2620 SVQTDDEDSA 2630 EWEQPVRRRR 2640 SRLPRHSDSG 2650 SDSKHDATAS 2660 SSSAAATVRA 2670 MSSVGIQTIS 2680 DCSVQTEPDQ 2690 LPRVSPAIHI 2700 TAATDPKVEI 2710 VRYISAPEKT 2720 GRGESLACQT 2730 EPDGQAQGVA 2740 GPQLVGPTAI 2750 SPYLPGIQIV 2760 TPGPLGRFEK 2770 KKPDPLEIGY 2780 QAHLPPESLS 2790 QLVSRQPPKS 2800 PQVLYSPVSP 2810 LSPHRLLDTS 2820 FASSERLNKA 2830 HVSPQKHFTA 2840 DSALRQQTLP 2850 RPMKTLQRSL 2860 SDPKPLSPTA 2870 EESAKERFSL 2880 YQHQGGLGSQ 2890 VSALPPNSLV 2900 RKVKRTLPSP 2910 PPEEAHLPLA 2920 GQASPQLYAA 2930 SLLQRGLTGP 2940 TTVPATKASL 2950 LRELDRDLRL 2960 VEHESTKLRK 2970 KQAELDEEEK 2980 EIDAKLKYLE 2990 LGITQRKESL 3000 AKDRGGRDYP 3010 PLRGLGEHRD 3020 YLSDSELNQL 3030 RLQGCTTPAG 3040 QFVDFPATAA 3050 APATPSGPTA 3060 FQQPRFQPPA 3070 PQYSAGSGGP 3080 TQNGFPAHQA 3090 PTYPGPSTYP 3100 APAFPPGASY 3110 PAEPGLPNQQ 3120 AFRPTGHYAG 3130 QTPMPTTQST 3140 LFPVPADSRA 3150 PLQKPRQTSL 3160 ADLEQKVPTN 3170 YEVIASPVVP 3180 MSSAPSETSY 3190 SGPAVSSGYE 3200 QGKVPEVPRA 3210 GDRGSVSQSP 3220 APTYPSDSHY 3230 TSLEQNVPRN 3240 YVMIDDISEL 3250 TKDSTSTAPD 3260 SQRLEPLGPG 3270 SSGRPGKEPG 3280 EPGVLDGPTL 3290 PCCYARGEEE 3300 SEEDSYDPRG 3310 KGGHLRSMES 3320 NGRPASTHYY 3330 GDSDYRHGAR 3340 VEKYGPGPMG 3350 PKHPSKSLAP 3360 AAISSKRSKH 3370 RKQGMEQKIS 3380 KFSPIEEAKD 3390 VESDLASYPP 3400 PAVSSSLVSR 3410 GRKFQDEITY 3420 GLKKNVYEQQ 3430 KYYGMSSRDA 3440 VEDDRIYGGS 3450 SRSRAPSAYS 3460 GEKLSSHDFS 3470 GWGKGYERER 3480 EAVERLQKAG 3490 PKPSSLSMAH 3500 SRVRPPMRSQ 3510 ASEEESPVSP 3520 LGRPRPAGGP 3530 LPPGGDTCPQ 3540 FCSSHSMPDV 3550 QEHVKDGPRA 3560 HAYKREEGYI 3570 LDDSHCVVSD 3580 SEAYHLGQEE 3590 TDWFDKPRDA 3600 RSDRFRHHGG 3610 HAVSSSSQKR 3620 GPARHSYHDY 3630 DEPPEEGLWP 3640 HDEGGPGRHA 3650 SAKEHRHGDH 3660 GRHSGRHTGE 3670 EPGRRAAKPH 3680 ARDLGRHEAR 3690 PHSQPSSAPA 3700 MPKKGQPGYP 3710 SSAEYSQPSR 3720 ASSAYHHASD 3730 SKKGSRQAHS 3740 GPAALQSKAE 3750 PQAQPQLQGR 3760 QAAPGPQQSQ 3770 SPSSRQIPSG 3780 AASRQPQTQQ 3790 QQQGLGLQPP 3800 QQALTQARLQ 3810 QQSQPTTRGS 3820 APAASQPAGK 3830 PQPGPSTATG 3840 PQPAGPPRAE 3850 QTNGSKGTAK 3860 APQQGRAPQA 3870 QPAPGPGPAG 3880 VKAGARPGGT 3890 PGAPAGQPGA 3900 DGESVFSKIL 3910 PGGAAEQAGK 3920 LTEAVSAFGK KFSSFW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0009986 cell surface
Cellular Component GO:0098683 cochlear hair cell ribbon synapse
Cellular Component GO:0048788 cytoskeleton of presynaptic active zone
Cellular Component GO:0030425 dendrite
Cellular Component GO:0060076 excitatory synapse
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0044306 neuron projection terminus
Cellular Component GO:0005634 nucleus
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0048786 presynaptic active zone
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0008021 synaptic vesicle
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0004857 enzyme inhibitor activity
Molecular Function GO:0098882 structural constituent of presynaptic active zone
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:1904071 presynaptic active zone assembly
Biological Process GO:0035418 protein localization to synapse
Biological Process GO:0098693 regulation of synaptic vesicle cycle
Biological Process GO:0097091 synaptic vesicle clustering

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.