Overview
| Uniprot ID | Q9UPN4 |
|---|
| Protein Name | Centrosomal protein of 131 kDa |
|---|
| Gene Name | CEP131 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 346 |
AIQELQQKRALRAQK |
Function
Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208)
Protein Sequence
10
MKGTRAIGSV
20
PERSPAGVDL
30
SLTGLPPPVS
40
RRPGSAATTK
50
PIVRSVSVVT
60
GSEQKRKVLE
70
ATGPGGSQAI
80
NNLRRSNSTT
90
QVSQPRSGSP
100
RPTEPTDFLM
110
LFEGSPSGKK
120
RPASLSTAPS
130
EKGATWNVLD
140
DQPRGFTLPS
150
NARSSSALDS
160
PAGPRRKECT
170
VALAPNFTAN
180
NRSNKGAVGN
190
CVTTMVHNRY
200
TPSERAPPLK
210
SSNQTAPSLN
220
NIIKAATCEG
230
SESSGFGKLP
240
KNVSSATHSA
250
RNNTGGSTGL
260
PRRKEVTEEE
270
AERFIHQVNQ
280
ATVTIQRWYR
290
HQVQRRGAGA
300
ARLEHLLQAK
310
REEQRQRSGE
320
GTLLDLHQQK
330
EAARRKAREE
340
KARQARRAAI
350
QELQQKRALR
360
AQKASTAERG
370
PPENPRETRV
380
PGMRQPAQEL
390
SPTPGGTAHQ
400
ALKANNTGGG
410
LPAAGPGDRC
420
LPTSDSSPEP
430
QQPPEDRTQD
440
VLAQDAAGDN
450
LEMMAPSRGS
460
AKSRGPLEEL
470
LHTLQLLEKE
480
PDVLPRPRTH
490
HRGRYAWASE
500
VTTEDDASSL
510
TADNLEKFGK
520
LSAFPEPPED
530
GTLLSEAKLQ
540
SIMSFLDEME
550
KSGQDQLDSQ
560
QEGWVPEAGP
570
GPLELGSEVS
580
TSVMRLKLEV
590
EEKKQAMLLL
600
QRALAQQRDL
610
TARRVKETEK
620
ALSRQLQRQR
630
EHYEATIQRH
640
LAFIDQLIED
650
KKVLSEKCEA
660
VVAELKQEDQ
670
RCTERVAQAQ
680
AQHELEIKKL
690
KELMSATEKA
700
RREKWISEKT
710
KKIKEVTVRG
720
LEPEIQKLIA
730
RHKQEVRRLK
740
SLHEAELLQS
750
DERASQRCLR
760
QAEELREQLE
770
REKEALGQQE
780
RERARQRFQQ
790
HLEQEQWALQ
800
QQRQRLYSEV
810
AEERERLGQQ
820
AARQRAELEE
830
LRQQLEESSS
840
ALTRALRAEF
850
EKGREEQERR
860
HQMELNTLKQ
870
QLELERQAWE
880
AGRTRKEEAW
890
LLNREQELRE
900
EIRKGRDKEI
910
ELVIHRLEAD
920
MALAKEESEK
930
AAESRIKRLR
940
DKYEAELSEL
950
EQSERKLQER
960
CSELKGQLGE
970
AEGENLRLQG
980
LVRQKERALE
990
DAQAVNEQLS
1000
SERSNLAQVI
1010
RQEFEDRLAA
1020
SEEETRQAKA
1030
ELATLQARQQ
1040
LELEEVHRRV
1050
KTALARKEEA
1060
VSSLRTQHEA
1070
AVKRADHLEE
1080
LLEQHRRPTP
STK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0001669 |
acrosomal vesicle |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0035869 |
ciliary transition zone |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0120212 |
sperm head-tail coupling apparatus |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0035735 |
intraciliary transport involved in cilium assembly |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0090316 |
positive regulation of intracellular protein transport |
| Biological Process |
GO:0071539 |
protein localization to centrosome |
| Biological Process |
GO:0010824 |
regulation of centrosome duplication |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.