Search Results

Overview

Uniprot ID	Q9UPQ0
Protein Name	LIM and calponin homology domains-containing protein 1
Gene Name	LIMCH1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
296	AEREEYRKSWSTATS
545	PKPYSQPKNSQDVLK
874	KQDRRWKKSFQGDDS

Function

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration

Protein Sequence

10 MACPALGLEA 20 LQPLQPEPPP 30 EPAFSEAQKW 40 IEQVTGRSFG 50 DKDFRTGLEN 60 GILLCELLNA 70 IKPGLVKKIN 80 RLPTPIAGLD 90 NIILFLRGCK 100 ELGLKESQLF 110 DPSDLQDTSN 120 RVTVKSLDYS 130 RKLKNVLVTI 140 YWLGKAANSC 150 TSYSGTTLNL 160 KEFEGLLAQM 170 RKDTDDIESP 180 KRSIRDSGYI 190 DCWDSERSDS 200 LSPPRHGRDD 210 SFDSLDSFGS 220 RSRQTPSPDV 230 VLRGSSDGRG 240 SDSESDLPHR 250 KLPDVKKDDM 260 SARRTSHGEP 270 KSAVPFNQYL 280 PNKSNQTAYV 290 PAPLRKKKAE 300 REEYRKSWST 310 ATSPLGGERP 320 FRYGPRTPVS 330 DDAESTSMFD 340 MRCEEEAAVQ 350 PHSRARQEQL 360 QLINNQLREE 370 DDKWQDDLAR 380 WKSRRRSVSQ 390 DLIKKEEERK 400 KMEKLLAGED 410 GTSERRKSIK 420 TYREIVQEKE 430 RRERELHEAY 440 KNARSQEEAE 450 GILQQYIERF 460 TISEAVLERL 470 EMPKILERSH 480 STEPNLSSFL 490 NDPNPMKYLR 500 QQSLPPPKFT 510 ATVETTIARA 520 SVLDTSMSAG 530 SGSPSKTVTP 540 KAVPMLTPKP 550 YSQPKNSQDV 560 LKTFKVDGKV 570 SVNGETVHRE 580 EEKERECPTV 590 APAHSLTKSQ 600 MFEGVARVHG 610 SPLELKQDNG 620 SIEINIKKPN 630 SVPQELAATT 640 EKTEPNSQED 650 KNDGGKSRKG 660 NIELASSEPQ 670 HFTTTVTRCS 680 PTVAFVEFPS 690 SPQLKNDVSE 700 EKDQKKPENE 710 MSGKVELVLS 720 QKVVKPKSPE 730 PEATLTFPFL 740 DKMPEANQLH 750 LPNLNSQVDS 760 PSSEKSPVMT 770 PQFKFWAWDP 780 EEERRRQEKW 790 QQEQERLLQE 800 RYQKEQDKLK 810 EEWEKAQKEV 820 EEEERRYYEE 830 ERKIIEDTVV 840 PFTVSSSSAD 850 QLSTSSSMTE 860 GSGTMNKIDL 870 GNCQDEKQDR 880 RWKKSFQGDD 890 SDLLLKTRES 900 DRLEEKGSLT 910 EGALAHSGNP 920 VSKGVHEDHQ 930 LDTEAGAPHC 940 GTNPQLAQDP 950 SQNQQTSNPT 960 HSSEDVKPKT 970 LPLDKSINHQ 980 IESPSERRKK 990 SPREHFQAGP 1000 FSPCSPTPPG 1010 QSPNRSISGK 1020 KLCSSCGLPL 1030 GKGAAMIIET 1040 LNLYFHIQCF 1050 RCGICKGQLG 1060 DAVSGTDVRI 1070 RNGLLNCNDC 1080 YMRSRSAGQP TTL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0032034	myosin II head/neck binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0060327	cytoplasmic actin-based contraction involved in cell motility
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:0051496	positive regulation of stress fiber assembly
Biological Process	GO:0051893	regulation of focal adhesion assembly

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.