Search Results

Overview

Uniprot IDQ9UPT8
Protein NameZinc finger CCCH domain-containing protein 4
Gene NameZC3H4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1051 ELLSRILKTVNATGS
1159 RTPNAGGKATEPAAD
1184 NGKSSASKAKEPPFV
1186 KSSASKAKEPPFVRK
1193 KEPPFVRKSALEQPE
1224 SYNRPRPKAAAAPAA
184 LPKKAYSKMDSKSYG
776 LYLRIQQKQQEEEER
851 LGDPRLQKGHPTGSR

Function

RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452)

Protein Sequence

10 MEAAPGTPPP 20 PPSESPPPPS 30 PPPPSTPSPP 40 PCSPDARPAT 50 PHLLHHRLPL 60 PDDREDGELE 70 EGELEDDGAE 80 ETQDTSGGPE 90 RSRKEKGEKH 100 HSDSDEEKSH 110 RRLKRKRKKE 120 REKEKRRSKK 130 RRKSKHKRHA 140 SSSDDFSDFS 150 DDSDFSPSEK 160 GHRKYREYSP 170 PYAPSHQQYP 180 PSHATPLPKK 190 AYSKMDSKSY 200 GMYEDYENEQ 210 YGEYEGDEEE 220 DMGKEDYDDF 230 TKELNQYRRA 240 KEGSSRGRGS 250 RGRGRGYRGR 260 GSRGGSRGRG 270 MGRGSRGRGR 280 GSMGGDHPED 290 EEDFYEEEMD 300 YGESEEPMGD 310 DDYDEYSKEL 320 NQYRRSKDSR 330 GRGLSRGRGR 340 GSRGRGKGMG 350 RGRGRGGSRG 360 GMNKGGMNDD 370 EDFYDEDMGD 380 GGGGSYRSRD 390 HDKPHQQSDK 400 KGKVICKYFV 410 EGRCTWGDHC 420 NFSHDIELPK 430 KRELCKFYIT 440 GFCARAENCP 450 YMHGDFPCKL 460 YHTTGNCING 470 DDCMFSHDPL 480 TEETRELLDK 490 MLADDAEAGA 500 EDEKEVEELK 510 KQGINPLPKP 520 PPGVGLLPTP 530 PRPPGPQAPT 540 SPNGRPMQGG 550 PPPPPPPPPP 560 PPGPPQMPMP 570 VHEPLSPQQL 580 QQQDMYNKKI 590 PSLFEIVVRP 600 TGQLAEKLGV 610 RFPGPGGPPG 620 PMGPGPNMGP 630 PGPMGGPMHP 640 DMHPDMHPDM 650 HPDMHADMHA 660 DMPMGPGMNP 670 GPPMGPGGPP 680 MMPYGPGDSP 690 HSGMMPPIPP 700 AQNFYENFYQ 710 QQEGMEMEPG 720 LLGDAEDYGH 730 YEELPGEPGE 740 HLFPEHPLEP 750 DSFSEGGPPG 760 RPKPGAGVPD 770 FLPSAQRALY 780 LRIQQKQQEE 790 EERARRLAES 800 SKQDRENEEG 810 DTGNWYSSDE 820 DEGGSSVTSI 830 LKTLRQQTSS 840 RPPASVGELS 850 SSGLGDPRLQ 860 KGHPTGSRLA 870 DPRLSRDPRL 880 TRHVEASGGS 890 GPGDSGPSDP 900 RLARALPTSK 910 PEGSLHSSPV 920 GPSSSKGSGP 930 PPTEEEEGER 940 ALREKAVNIP 950 LDPLPGHPLR 960 DPRSQLQQFS 970 HIKKDVTLSK 980 PSFARTVLWN 990 PEDLIPLPIP 1000 KQDAVPPVPA 1010 ALQSMPTLDP 1020 RLHRAATAGP 1030 PNARQRPGAS 1040 TDSSTQGANL 1050 PDFELLSRIL 1060 KTVNATGSSA 1070 APGSSDKPSD 1080 PRVRKAPTDP 1090 RLQKPTDSTA 1100 SSRAAKPGPA 1110 EAPSPTASPS 1120 GDASPPATAP 1130 YDPRVLAAGG 1140 LGQGGGGGQS 1150 SVLSGISLYD 1160 PRTPNAGGKA 1170 TEPAADTGAQ 1180 PKGAEGNGKS 1190 SASKAKEPPF 1200 VRKSALEQPE 1210 TGKAGADGGT 1220 PTDRYNSYNR 1230 PRPKAAAAPA 1240 ATTATPPPEG 1250 APPQPGVHNL 1260 PVPTLFGTVK 1270 QTPKTGSGSP 1280 FAGNSPAREG 1290 EQDAASLKDV 1300 FKGFDPTASP FCQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006353 DNA-templated transcription termination
Biological Process GO:0110064 lncRNA catabolic process
Biological Process GO:0032785 negative regulation of DNA-templated transcription, elongation
Biological Process GO:0140744 negative regulation of lncRNA transcription
Biological Process GO:0071027 nuclear RNA surveillance

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.