Search Results

Overview

Uniprot IDQ9UPU5
Protein NameUbiquitin carboxyl-terminal hydrolase 24
Gene NameUSP24
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2097 DRLSILTKLVKKGEK

Function

Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron

Protein Sequence

10 MESEEEQHMT 20 TLLCMGFSDP 30 ATIRKALRLA 40 KNDINEAVAL 50 LTNERPGLDY 60 GGYEPMDSGG 70 GPSPGPGGGP 80 RGDGGGDGGG 90 GGPSRGGSTG 100 GGGGFDPPPA 110 YHEVVDAEKN 120 DENGNCSGEG 130 IEFPTTNLYE 140 LESRVLTDHW 150 SIPYKREESL 160 GKCLLASTYL 170 ARLGLSESDE 180 NCRRFMDRCM 190 PEAFKKLLTS 200 SAVHKWGTEI 210 HEGIYNMLML 220 LIELVAERIK 230 QDPIPTGLLG 240 VLTMAFNPDN 250 EYHFKNRMKV 260 SQRNWAEVFG 270 EGNMFAVSPV 280 STFQKEPHGW 290 VVDLVNKFGE 300 LGGFAAIQAK 310 LHSEDIELGA 320 VSALIQPLGV 330 CAEYLNSSVV 340 QPMLDPVILT 350 TIQDVRSVEE 360 KDLKDKRLVS 370 IPELLSAVKL 380 LCMRFQPDLV 390 TIVDDLRLDI 400 LLRMLKSPHF 410 SAKMNSLKEV 420 TKLIEDSTLS 430 KSVKNAIDTD 440 RLLDWLVENS 450 VLSIALEGNI 460 DQAQYCDRIK 470 GIIELLGSKL 480 SLDELTKIWK 490 IQSGQSSTVI 500 ENIHTIIAAA 510 AVKFNSDQLN 520 HLFVLIQKSW 530 ETESDRVRQK 540 LLSLIGRIGR 550 EARFETTSGK 560 VLDVLWELAH 570 LPTLPSSLIQ 580 QALEEHLTIL 590 SDAYAVKEAI 600 KRSYIIKCIE 610 DIKRPGEWSG 620 LEKNKKDGFK 630 SSQLNNPQFV 640 WVVPALRQLH 650 EITRSFIKQT 660 YQKQDKSIIQ 670 DLKKNFEIVK 680 LVTGSLIACH 690 RLAAAVAGPG 700 GLSGSTLVDG 710 RYTYREYLEA 720 HLKFLAFFLQ 730 EATLYLGWNR 740 AKEIWECLVT 750 GQDVCELDRE 760 MCFEWFTKGQ 770 HDLESDVQQQ 780 LFKEKILKLE 790 SYEITMNGFN 800 LFKTFFENVN 810 LCDHRLKRQG 820 AQLYVEKLEL 830 IGMDFIWKIA 840 MESPDEEIAN 850 EAIQLIINYS 860 YINLNPRLKK 870 DSVSLHKKFI 880 ADCYTRLEAA 890 SSALGGPTLT 900 HAVTRATKML 910 TATAMPTVAT 920 SVQSPYRSTK 930 LVIIERLLLL 940 AERYVITIED 950 FYSVPRTILP 960 HGASFHGHLL 970 TLNVTYESTK 980 DTFTVEAHSN 990 ETIGSVRWKI 1000 AKQLCSPVDN 1010 IQIFTNDSLL 1020 TVNKDQKLLH 1030 QLGFSDEQIL 1040 TVKTSGSGTP 1050 SGSSADSSTS 1060 SSSSSSGVFS 1070 SSYAMEQEKS 1080 LPGVVMALVC 1090 NVFDMLYQLA 1100 NLEEPRITLR 1110 VRKLLLLIPT 1120 DPAIQEALDQ 1130 LDSLGRKKTL 1140 LSESSSQSSK 1150 SPSLSSKQQH 1160 QPSASSILES 1170 LFRSFAPGMS 1180 TFRVLYNLEV 1190 LSSKLMPTAD 1200 DDMARSCAKS 1210 FCENFLKAGG 1220 LSLVVNVMQR 1230 DSIPSEVDYE 1240 TRQGVYSICL 1250 QLARFLLVGQ 1260 TMPTLLDEDL 1270 TKDGIEALSS 1280 RPFRNVSRQT 1290 SRQMSLCGTP 1300 EKSSYRQLSV 1310 SDRSSIRVEE 1320 IIPAARVAIQ 1330 TMEVSDFTST 1340 VACFMRLSWA 1350 AAAGRLDLVG 1360 SSQPIKESNS 1370 LCPAGIRNRL 1380 SSSGSNCSSG 1390 SEGEPVALHA 1400 GICVRQQSVS 1410 TKDSLIAGEA 1420 LSLLVTCLQL 1430 RSQQLASFYN 1440 LPCVADFIID 1450 ILLGSPSAEI 1460 RRVACDQLYT 1470 LSQTDTSAHP 1480 DVQKPNQFLL 1490 GVILTAQLPL 1500 WSPTSIMRGV 1510 NQRLLSQCME 1520 YFDLRCQLLD 1530 DLTTSEMEQL 1540 RISPATMLED 1550 EITWLDNFEP 1560 NRTAECETSE 1570 ADNILLAGHL 1580 RLIKTLLSLC 1590 GAEKEMLGSS 1600 LIKPLLDDFL 1610 FRASRIILNS 1620 HSPAGSAAIS 1630 QQDFHPKCST 1640 ANSRLAAYEV 1650 LVMLADSSPS 1660 NLQIIIKELL 1670 SMHHQPDPAL 1680 TKEFDYLPPV 1690 DSRSSSGFVG 1700 LRNGGATCYM 1710 NAVFQQLYMQ 1720 PGLPESLLSV 1730 DDDTDNPDDS 1740 VFYQVQSLFG 1750 HLMESKLQYY 1760 VPENFWKIFK 1770 MWNKELYVRE 1780 QQDAYEFFTS 1790 LIDQMDEYLK 1800 KMGRDQIFKN 1810 TFQGIYSDQK 1820 ICKDCPHRYE 1830 REEAFMALNL 1840 GVTSCQSLEI 1850 SLDQFVRGEV 1860 LEGSNAYYCE 1870 KCKEKRITVK 1880 RTCIKSLPSV 1890 LVIHLMRFGF 1900 DWESGRSIKY 1910 DEQIRFPWML 1920 NMEPYTVSGM 1930 ARQDSSSEVG 1940 ENGRSVDQGG 1950 GGSPRKKVAL 1960 TENYELVGVI 1970 VHSGQAHAGH 1980 YYSFIKDRRG 1990 CGKGKWYKFN 2000 DTVIEEFDLN 2010 DETLEYECFG 2020 GEYRPKVYDQ 2030 TNPYTDVRRR 2040 YWNAYMLFYQ 2050 RVSDQNSPVL 2060 PKKSRVSVVR 2070 QEAEDLSLSA 2080 PSSPEISPQS 2090 SPRPHRPNND 2100 RLSILTKLVK 2110 KGEKKGLFVE 2120 KMPARIYQMV 2130 RDENLKFMKN 2140 RDVYSSDYFS 2150 FVLSLASLNA 2160 TKLKHPYYPC 2170 MAKVSLQLAI 2180 QFLFQTYLRT 2190 KKKLRVDTEE 2200 WIATIEALLS 2210 KSFDACQWLV 2220 EYFISSEGRE 2230 LIKIFLLECN 2240 VREVRVAVAT 2250 ILEKTLDSAL 2260 FYQDKLKSLH 2270 QLLEVLLALL 2280 DKDVPENCKN 2290 CAQYFFLFNT 2300 FVQKQGIRAG 2310 DLLLRHSALR 2320 HMISFLLGAS 2330 RQNNQIRRWS 2340 SAQAREFGNL 2350 HNTVALLVLH 2360 SDVSSQRNVA 2370 PGIFKQRPPI 2380 SIAPSSPLLP 2390 LHEEVEALLF 2400 MSEGKPYLLE 2410 VMFALRELTG 2420 SLLALIEMVV 2430 YCCFCNEHFS 2440 FTMLHFIKNQ 2450 LETAPPHELK 2460 NTFQLLHEIL 2470 VIEDPIQVER 2480 VKFVFETENG 2490 LLALMHHSNH 2500 VDSSRCYQCV 2510 KFLVTLAQKC 2520 PAAKEYFKEN 2530 SHHWSWAVQW 2540 LQKKMSEHYW 2550 TPQSNVSNET 2560 STGKTFQRTI 2570 SAQDTLAYAT 2580 ALLNEKEQSG 2590 SSNGSESSPA 2600 NENGDRHLQQ 2610 GSESPMMIGE 2620 LRSDLDDVDP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0031647 regulation of protein stability

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.