Search Results

Overview

Uniprot ID	Q9UPW0
Protein Name	Forkhead box protein J3
Gene Name	FOXJ3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
41	TMRAAIQKSDATQNA
55	AHGTGISKKNALLDP
56	HGTGISKKNALLDPN

Function

Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity)

Protein Sequence

10 MGLYGQACPS 20 VTSLRMTSEL 30 ESSLTSMDWL 40 PQLTMRAAIQ 50 KSDATQNAHG 60 TGISKKNALL 70 DPNTTLDQEE 80 VQQHKDGKPP 90 YSYASLITFA 100 INSSPKKKMT 110 LSEIYQWICD 120 NFPYYREAGS 130 GWKNSIRHNL 140 SLNKCFLKVP 150 RSKDDPGKGS 160 YWAIDTNPKE 170 DVLPTRPKKR 180 ARSVERASTP 190 YSIDSDSLGM 200 ECIISGSASP 210 TLAINTVTNK 220 VTLYNTDQDG 230 SDSPRSSLNN 240 SLSDQSLASV 250 NLNSVGSVHS 260 YTPVTSHPES 270 VSQSLTPQQQ 280 PQYNLPERDK 290 QLLFSEYNFE 300 DLSASFRSLY 310 KSVFEQSLSQ 320 QGLMNIPSES 330 SQQSHTSCTY 340 QHSPSSTVST 350 HPHSNQSSLS 360 NSHGSGLNTT 370 GSNSVAQVSL 380 SHPQMHTQPS 390 PHPPHRPHGL 400 PQHPQRSPHP 410 APHPQQHSQL 420 QSPHPQHPSP 430 HQHIQHHPNH 440 QHQTLTHQAP 450 PPPQQVSCNS 460 GVSNDWYATL 470 DMLKESCRIA 480 SSVNWSDVDL 490 SQFQGLMESM 500 RQADLKNWSL 510 DQVQFADLCS 520 SLNQFFTQTG 530 LIHSQSNVQQ 540 NVCHGAMHPT 550 KPSQHIGTGN 560 LYIDSRQNLP 570 PSVMPPPGYP 580 HIPQALSTPG 590 TTMAGHHRAM 600 NQQHMMPSQA 610 FQMRRSLPPD 620 DIQDDFDWDS IV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007141	male meiosis I
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0007283	spermatogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.