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Overview

Uniprot IDQ9UPW6
Protein NameDNA-binding protein SATB2
Gene NameSATB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
30 VKGPPPVKVARLEQN
464 SSRTPQAKTSTPTTD

Function

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation

Protein Sequence

10 MERRSESPCL 20 RDSPDRRSGS 30 PDVKGPPPVK 40 VARLEQNGSP 50 MGARGRPNGA 60 VAKAVGGLMI 70 PVFCVVEQLD 80 GSLEYDNREE 90 HAEFVLVRKD 100 VLFSQLVETA 110 LLALGYSHSS 120 AAQAQGIIKL 130 GRWNPLPLSY 140 VTDAPDATVA 150 DMLQDVYHVV 160 TLKIQLQSCS 170 KLEDLPAEQW 180 NHATVRNALK 190 ELLKEMNQST 200 LAKECPLSQS 210 MISSIVNSTY 220 YANVSATKCQ 230 EFGRWYKKYK 240 KIKVERVERE 250 NLSDYCVLGQ 260 RPMHLPNMNQ 270 LASLGKTNEQ 280 SPHSQIHHST 290 PIRNQVPALQ 300 PIMSPGLLSP 310 QLSPQLVRQQ 320 IAMAHLINQQ 330 IAVSRLLAHQ 340 HPQAINQQFL 350 NHPPIPRAVK 360 PEPTNSSVEV 370 SPDIYQQVRD 380 ELKRASVSQA 390 VFARVAFNRT 400 QGLLSEILRK 410 EEDPRTASQS 420 LLVNLRAMQN 430 FLNLPEVERD 440 RIYQDERERS 450 MNPNVSMVSS 460 ASSSPSSSRT 470 PQAKTSTPTT 480 DLPIKVDGAN 490 INITAAIYDE 500 IQQEMKRAKV 510 SQALFAKVAA 520 NKSQGWLCEL 530 LRWKENPSPE 540 NRTLWENLCT 550 IRRFLNLPQH 560 ERDVIYEEES 570 RHHHSERMQH 580 VVQLPPEPVQ 590 VLHRQQSQPA 600 KESSPPREEA 610 PPPPPPTEDS 620 CAKKPRSRTK 630 ISLEALGILQ 640 SFIHDVGLYP 650 DQEAIHTLSA 660 QLDLPKHTII 670 KFFQNQRYHV 680 KHHGKLKEHL 690 GSAVDVAEYK 700 DEELLTESEE 710 NDSEEGSEEM 720 YKVEAEEENA 730 DKSKAAPAEI DQR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.