Search Results

Overview

Uniprot IDQ9UPX8
Protein NameSH3 and multiple ankyrin repeat domains protein 2
Gene NameSHANK2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1603 VLQPRTSKLWGDVTE

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction

Protein Sequence

10 MPRSPTSSED 20 EMAQSFSDYS 30 VGSESDSSKE 40 ETIYDTIRAT 50 AEKPGGARTE 60 ESQGNTLVIR 70 VVIHDLQQTK 80 CIRFNPDATV 90 WVAKQRILCT 100 LTQSLKDVLN 110 YGLFQPASNG 120 RDGKFLDEER 130 LLREYPQPVG 140 EGVPSLEFRY 150 KKRVYKQASL 160 DEKQLAKLHT 170 KTNLKKCMDH 180 IQHRLVEKIT 190 KMLDRGLDPN 200 FHDPETGETP 210 LTLAAQLDDS 220 VEVIKALKNG 230 GAHLDFRAKD 240 GMTALHKAAR 250 ARNQVALKTL 260 LELGASPDYK 270 DSYGLTPLYH 280 TAIVGGDPYC 290 CELLLHEHAT 300 VCCKDENGWH 310 EIHQACRYGH 320 VQHLEHLLFY 330 GADMSAQNAS 340 GNTALHICAL 350 YNQDSCARVL 360 LFRGGNKELK 370 NYNSQTPFQV 380 AIIAGNFELA 390 EYIKNHKETD 400 IVPFREAPAY 410 SNRRRRPPNT 420 LAAPRVLLRS 430 NSDNNLNASA 440 PDWAVCSTAT 450 SHRSLSPQLL 460 QQMPSKPEGA 470 AKTIGSYVPG 480 PRSRSPSLNR 490 LGGAGEDGKR 500 PQPLWHVGSP 510 FALGANKDSL 520 SAFEYPGPKR 530 KLYSAVPGRL 540 FVAVKPYQPQ 550 VDGEIPLHRG 560 DRVKVLSIGE 570 GGFWEGSARG 580 HIGWFPAECV 590 EEVQCKPRDS 600 QAETRADRSK 610 KLFRHYTVGS 620 YDSFDTSSDC 630 IIEEKTVVLQ 640 KKDNEGFGFV 650 LRGAKADTPI 660 EEFTPTPAFP 670 ALQYLESVDE 680 GGVAWQAGLR 690 TGDFLIEVNN 700 ENVVKVGHRQ 710 VVNMIRQGGN 720 HLVLKVVTVT 730 RNLDPDDTAR 740 KKAPPPPKRA 750 PTTALTLRSK 760 SMTSELEELV 770 DKASVRKKKD 780 KPEEIVPASK 790 PSRAAENMAV 800 EPRVATIKQR 810 PSSRCFPAGS 820 DMNSVYERQG 830 IAVMTPTVPG 840 SPKAPFLGIP 850 RGTMRRQKSI 860 DSRIFLSGIT 870 EEERQFLAPP 880 MLKFTRSLSM 890 PDTSEDIPPP 900 PQSVPPSPPP 910 PSPTTYNCPK 920 SPTPRVYGTI 930 KPAFNQNSAA 940 KVSPATRSDT 950 VATMMREKGM 960 YFRRELDRYS 970 LDSEDLYSRN 980 AGPQANFRNK 990 RGQMPENPYS 1000 EVGKIASKAV 1010 YVPAKPARRK 1020 GMLVKQSNVE 1030 DSPEKTCSIP 1040 IPTIIVKEPS 1050 TSSSGKSSQG 1060 SSMEIDPQAP 1070 EPPSQLRPDE 1080 SLTVSSPFAA 1090 AIAGAVRDRE 1100 KRLEARRNSP 1110 AFLSTDLGDE 1120 DVGLGPPAPR 1130 TRPSMFPEEG 1140 DFADEDSAEQ 1150 LSSPMPSATP 1160 REPENHFVGG 1170 AEASAPGEAG 1180 RPLNSTSKAQ 1190 GPESSPAVPS 1200 ASSGTAGPGN 1210 YVHPLTGRLL 1220 DPSSPLALAL 1230 SARDRAMKES 1240 QQGPKGEAPK 1250 ADLNKPLYID 1260 TKMRPSLDAG 1270 FPTVTRQNTR 1280 GPLRRQETEN 1290 KYETDLGRDR 1300 KGDDKKNMLI 1310 DIMDTSQQKS 1320 AGLLMVHTVD 1330 ATKLDNALQE 1340 EDEKAEVEMK 1350 PDSSPSEVPE 1360 GVSETEGALQ 1370 ISAAPEPTTV 1380 PGRTIVAVGS 1390 MEEAVILPFR 1400 IPPPPLASVD 1410 LDEDFIFTEP 1420 LPPPLEFANS 1430 FDIPDDRAAS 1440 VPALSDLVKQ 1450 KKSDTPQSPS 1460 LNSSQPTNSA 1470 DSKKPASLSN 1480 CLPASFLPPP 1490 ESFDAVADSG 1500 IEEVDSRSSS 1510 DHHLETTSTI 1520 STVSSISTLS 1530 SEGGENVDTC 1540 TVYADGQAFM 1550 VDKPPVPPKP 1560 KMKPIIHKSN 1570 ALYQDALVEE 1580 DVDSFVIPPP 1590 APPPPPGSAQ 1600 PGMAKVLQPR 1610 TSKLWGDVTE 1620 IKSPILSGPK 1630 ANVISELNSI 1640 LQQMNREKLA 1650 KPGEGLDSPM 1660 GAKSASLAPR 1670 SPEIMSTISG 1680 TRSTTVTFTV 1690 RPGTSQPITL 1700 QSRPPDYESR 1710 TSGTRRAPSP 1720 VVSPTEMNKE 1730 TLPAPLSAAT 1740 ASPSPALSDV 1750 FSLPSQPPSG 1760 DLFGLNPAGR 1770 SRSPSPSILQ 1780 QPISNKPFTT 1790 KPVHLWTKPD 1800 VADWLESLNL 1810 GEHKEAFMDN 1820 EIDGSHLPNL 1830 QKEDLIDLGV 1840 TRVGHRMNIE RALKQLLDR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0031526 brush border membrane
Cellular Component GO:0060170 ciliary membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0030426 growth cone
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0001750 photoreceptor outer segment
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Molecular Function GO:0035255 ionotropic glutamate receptor binding
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0030160 synaptic receptor adaptor activity
Biological Process GO:0030534 adult behavior
Biological Process GO:0008306 associative learning
Biological Process GO:0007612 learning
Biological Process GO:0060292 long-term synaptic depression
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0035331 negative regulation of hippo signaling
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0035176 social behavior
Biological Process GO:0007416 synapse assembly
Biological Process GO:0050808 synapse organization
Biological Process GO:0071625 vocalization behavior

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.