Search Results
Overview
| Uniprot ID | Q9UPY8 |
|---|---|
| Protein Name | Microtubule-associated protein RP/EB family member 3 |
| Gene Name | MAPRE3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | PGDQIFNKSKKLIGT |
| 151 | QIFNKSKKLIGTAVP |
| 167 | RTSPTGPKNMQTSGR |
| 221 | LTVDGLEKERDFYFS |
Function
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:19255245, PubMed:28814570). Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:19255245, PubMed:28814570). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:1905721 | mitotic spindle astral microtubule end |
| Cellular Component | GO:0098984 | neuron to neuron synapse |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0051233 | spindle midzone |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Biological Process | GO:0048148 | behavioral response to cocaine |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0035372 | protein localization to microtubule |
| Biological Process | GO:0031113 | regulation of microtubule polymerization |
| Biological Process | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| Biological Process | GO:0051225 | spindle assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.