Overview
| Uniprot ID | Q9UQ13 |
|---|
| Protein Name | Leucine-rich repeat protein SHOC-2 |
|---|
| Gene Name | SHOC2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 84 |
PAPGTRKKSSNAEVI |
Function
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (PubMed:10783161, PubMed:16630891, PubMed:25137548, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Acts as a scaffolding protein in the SMP complex (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:10783161, PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). Acts as an inhibitor of keratinocyte differentiation via interaction with RAS protein complexes that promote ERK activation (PubMed:23524970)
Protein Sequence
10
MSSSLGKEKD
20
SKEKDPKVPS
30
AKEREKEAKA
40
SGGFGKESKE
50
KEPKTKGKDA
60
KDGKKDSSAA
70
QPGVAFSVDN
80
TIKRPNPAPG
90
TRKKSSNAEV
100
IKELNKCREE
110
NSMRLDLSKR
120
SIHILPSSIK
130
ELTQLTELYL
140
YSNKLQSLPA
150
EVGCLVNLMT
160
LALSENSLTS
170
LPDSLDNLKK
180
LRMLDLRHNK
190
LREIPSVVYR
200
LDSLTTLYLR
210
FNRITTVEKD
220
IKNLSKLSML
230
SIRENKIKQL
240
PAEIGELCNL
250
ITLDVAHNQL
260
EHLPKEIGNC
270
TQITNLDLQH
280
NELLDLPDTI
290
GNLSSLSRLG
300
LRYNRLSAIP
310
RSLAKCSALE
320
ELNLENNNIS
330
TLPESLLSSL
340
VKLNSLTLAR
350
NCFQLYPVGG
360
PSQFSTIYSL
370
NMEHNRINKI
380
PFGIFSRAKV
390
LSKLNMKDNQ
400
LTSLPLDFGT
410
WTSMVELNLA
420
TNQLTKIPED
430
VSGLVSLEVL
440
ILSNNLLKKL
450
PHGLGNLRKL
460
RELDLEENKL
470
ESLPNEIAYL
480
KDLQKLVLTN
490
NQLTTLPRGI
500
GHLTNLTHLG
510
LGENLLTHLP
520
EEIGTLENLE
530
ELYLNDNPNL
540
HSLPFELALC
550
SKLSIMSIEN
560
CPLSHLPPQI
570
VAGGPSFIIQ
580
FLKMQGPYRA
MV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000164 |
protein phosphatase type 1 complex |
| Molecular Function |
GO:0008157 |
protein phosphatase 1 binding |
| Molecular Function |
GO:0019903 |
protein phosphatase binding |
| Molecular Function |
GO:0019888 |
protein phosphatase regulator activity |
| Biological Process |
GO:0071378 |
cellular response to growth hormone stimulus |
| Biological Process |
GO:0140361 |
cyclic-GMP-AMP transmembrane import across plasma membrane |
| Biological Process |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:2000178 |
negative regulation of neural precursor cell proliferation |
| Biological Process |
GO:0045665 |
negative regulation of neuron differentiation |
| Biological Process |
GO:0038180 |
nerve growth factor signaling pathway |
| Biological Process |
GO:0045666 |
positive regulation of neuron differentiation |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0046579 |
positive regulation of Ras protein signal transduction |
| Biological Process |
GO:0043408 |
regulation of MAPK cascade |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.