Search Results

Overview

Uniprot IDQ9UQ35
Protein NameSerine/arginine repetitive matrix protein 2
Gene NameSRRM2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 FRLMLLEKDVNPGGK
1022 PCPQEKSKDSLVQSC
1167 ETAESKEKMALPPQE
1186 SPPRQKDKFSPFPVQ
1203 PESSLVFKDTLRTPP
130 QLAELNEKKNERLRA
131 LAELNEKKNERLRAA
1664 SSPEHPPKSRTARRG
2602 PPEPTPAKRKRRSSS
2680 RRSRSPRKPIDSLRD
285 RSRSAAAKTHTTALA
51 RLEAALVKRPNPDIL
920 SSPQPKVKAIISPRQ
998 GSISPYPKVKAQTPP

Function

Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MYNGIGLPTP 20 RGSGTNGYVQ 30 RNLSLVRGRR 40 GERPDYKGEE 50 ELRRLEAALV 60 KRPNPDILDH 70 ERKRRVELRC 80 LELEEMMEEQ 90 GYEEQQIQEK 100 VATFRLMLLE 110 KDVNPGGKEE 120 TPGQRPAVTE 130 THQLAELNEK 140 KNERLRAAFG 150 ISDSYVDGSS 160 FDPQRRAREA 170 KQPAPEPPKP 180 YSLVRESSSS 190 RSPTPKQKKK 200 KKKKDRGRRS 210 ESSSPRRERK 220 KSSKKKKHRS 230 ESESKKRKHR 240 SPTPKSKRKS 250 KDKKRKRSRS 260 TTPAPKSRRA 270 HRSTSADSAS 280 SSDTSRSRSR 290 SAAAKTHTTA 300 LAGRSPSPAS 310 GRRGEGDAPF 320 SEPGTTSTQR 330 PSSPETATKQ 340 PSSPYEDKDK 350 DKKEKSATRP 360 SPSPERSSTG 370 PEPPAPTPLL 380 AERHGGSPQP 390 LATTPLSQEP 400 VNPPSEASPT 410 RDRSPPKSPE 420 KLPQSSSSES 430 SPPSPQPTKV 440 SRHASSSPES 450 PKPAPAPGSH 460 REISSSPTSK 470 NRSHGRAKRD 480 KSHSHTPSRR 490 MGRSRSPATA 500 KRGRSRSRTP 510 TKRGHSRSRS 520 PQWRRSRSAQ 530 RWGRSRSPQR 540 RGRSRSPQRP 550 GWSRSRNTQR 560 RGRSRSARRG 570 RSHSRSPATR 580 GRSRSRTPAR 590 RGRSRSRTPA 600 RRRSRSRTPT 610 RRRSRSRTPA 620 RRGRSRSRTP 630 ARRRSRTRSP 640 VRRRSRSRSP 650 ARRSGRSRSR 660 TPARRGRSRS 670 RTPARRGRSR 680 SRTPARRSGR 690 SRSRTPARRG 700 RSRSRTPRRG 710 RSRSRSLVRR 720 GRSHSRTPQR 730 RGRSGSSSER 740 KNKSRTSQRR 750 SRSNSSPEMK 760 KSRISSRRSR 770 SLSSPRSKAK 780 SRLSLRRSLS 790 GSSPCPKQKS 800 QTPPRRSRSG 810 SSQPKAKSRT 820 PPRRSRSSSS 830 PPPKQKSKTP 840 SRQSHSSSSP 850 HPKVKSGTPP 860 RQGSITSPQA 870 NEQSVTPQRR 880 SCFESSPDPE 890 LKSRTPSRHS 900 CSGSSPPRVK 910 SSTPPRQSPS 920 RSSSPQPKVK 930 AIISPRQRSH 940 SGSSSPSPSR 950 VTSRTTPRRS 960 RSVSPCSNVE 970 SRLLPRYSHS 980 GSSSPDTKVK 990 PETPPRQSHS 1000 GSISPYPKVK 1010 AQTPPGPSLS 1020 GSKSPCPQEK 1030 SKDSLVQSCP 1040 GSLSLCAGVK 1050 SSTPPGESYF 1060 GVSSLQLKGQ 1070 SQTSPDHRSD 1080 TSSPEVRQSH 1090 SESPSLQSKS 1100 QTSPKGGRSR 1110 SSSPVTELAS 1120 RSPIRQDRGE 1130 FSASPMLKSG 1140 MSPEQSRFQS 1150 DSSSYPTVDS 1160 NSLLGQSRLE 1170 TAESKEKMAL 1180 PPQEDATASP 1190 PRQKDKFSPF 1200 PVQDRPESSL 1210 VFKDTLRTPP 1220 RERSGAGSSP 1230 ETKEQNSALP 1240 TSSQDEELME 1250 VVEKSEEPAG 1260 QILSHLSSEL 1270 KEMSTSNFES 1280 SPEVEERPAV 1290 SLTLDQSQSQ 1300 ASLEAVEVPS 1310 MASSWGGPHF 1320 SPEHKELSNS 1330 PLRENSFGSP 1340 LEFRNSGPLG 1350 TEMNTGFSSE 1360 VKEDLNGPFL 1370 NQLETDPSLD 1380 MKEQSTRSSG 1390 HSSSELSPDA 1400 VEKAGMSSNQ 1410 SISSPVLDAV 1420 PRTPSRERSS 1430 SASSPEMKDG 1440 LPRTPSRRSR 1450 SGSSPGLRDG 1460 SGTPSRHSLS 1470 GSSPGMKDIP 1480 RTPSRGRSEC 1490 DSSPEPKALP 1500 QTPRPRSRSP 1510 SSPELNNKCL 1520 TPQRERSGSE 1530 SSVDQKTVAR 1540 TPLGQRSRSG 1550 SSQELDVKPS 1560 ASPQERSESD 1570 SSPDSKAKTR 1580 TPLRQRSRSG 1590 SSPEVDSKSR 1600 LSPRRSRSGS 1610 SPEVKDKPRA 1620 APRAQSGSDS 1630 SPEPKAPAPR 1640 ALPRRSRSGS 1650 SSKGRGPSPE 1660 GSSSTESSPE 1670 HPPKSRTARR 1680 GSRSSPEPKT 1690 KSRTPPRRRS 1700 SRSSPELTRK 1710 ARLSRRSRSA 1720 SSSPETRSRT 1730 PPRHRRSPSV 1740 SSPEPAEKSR 1750 SSRRRRSASS 1760 PRTKTTSRRG 1770 RSPSPKPRGL 1780 QRSRSRSRRE 1790 KTRTTRRRDR 1800 SGSSQSTSRR 1810 RQRSRSRSRV 1820 TRRRRGGSGY 1830 HSRSPARQES 1840 SRTSSRRRRG 1850 RSRTPPTSRK 1860 RSRSRTSPAP 1870 WKRSRSRASP 1880 ATHRRSRSRT 1890 PLISRRRSRS 1900 RTSPVSRRRS 1910 RSRTSVTRRR 1920 SRSRASPVSR 1930 RRSRSRTPPV 1940 TRRRSRSRTP 1950 TTRRRSRSRT 1960 PPVTRRRSRS 1970 RTPPVTRRRS 1980 RSRTSPITRR 1990 RSRSRTSPVT 2000 RRRSRSRTSP 2010 VTRRRSRSRT 2020 SPVTRRRSRS 2030 RTPPAIRRRS 2040 RSRTPLLPRK 2050 RSRSRSPLAI 2060 RRRSRSRTPR 2070 TARGKRSLTR 2080 SPPAIRRRSA 2090 SGSSSDRSRS 2100 ATPPATRNHS 2110 GSRTPPVALN 2120 SSRMSCFSRP 2130 SMSPTPLDRC 2140 RSPGMLEPLG 2150 SSRTPMSVLQ 2160 QAGGSMMDGP 2170 GPRIPDHQRT 2180 SVPENHAQSR 2190 IALALTAISL 2200 GTARPPPSMS 2210 AAGLAARMSQ 2220 VPAPVPLMSL 2230 RTAPAANLAS 2240 RIPAASAAAM 2250 NLASARTPAI 2260 PTAVNLADSR 2270 TPAAAAAMNL 2280 ASPRTAVAPS 2290 AVNLADPRTP 2300 TAPAVNLAGA 2310 RTPAALAALS 2320 LTGSGTPPTA 2330 ANYPSSSRTP 2340 QAPASANLVG 2350 PRSAHATAPV 2360 NIAGSRTAAA 2370 LAPASLTSAR 2380 MAPALSGANL 2390 TSPRVPLSAY 2400 ERVSGRTSPP 2410 LLDRARSRTP 2420 PSAPSQSRMT 2430 SERAPSPSSR 2440 MGQAPSQSLL 2450 PPAQDQPRSP 2460 VPSAFSDQSR 2470 CLIAQTTPVA 2480 GSQSLSSGAV 2490 ATTTSSAGDH 2500 NGMLSVPAPG 2510 VPHSDVGEPP 2520 ASTGAQQPSA 2530 LAALQPAKER 2540 RSSSSSSSSS 2550 SSSSSSSSSS 2560 SSSSSSGSSS 2570 SDSEGSSLPV 2580 QPEVALKRVP 2590 SPTPAPKEAV 2600 REGRPPEPTP 2610 AKRKRRSSSS 2620 SSSSSSSSSS 2630 SSSSSSSSSS 2640 SSSSSSSSSS 2650 SSSSSSSSPS 2660 PAKPGPQALP 2670 KPASPKKPPP 2680 GERRSRSPRK 2690 PIDSLRDSRS 2700 LSYSPVERRR 2710 PSPQPSPRDQ 2720 QSSSSERGSR 2730 RGQRGDSRSP 2740 SHKRRRETPS 2750 PRPMRHRSSR SP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Molecular Function GO:0070742 C2H2 zinc finger domain binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.