Search Results

Overview

Uniprot IDQ9UQ80
Protein NameProliferation-associated protein 2G4
Gene NamePA2G4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
210 QNPTDQQKKDHEKAE
211 NPTDQQKKDHEKAEF
22 DLVVTKYKMGGDIAN
253 IYKRDPSKQYGLKMK
287 LRAFEDEKKARMGVV
373 TQKKKKKKASKTAEN
376 KKKKKASKTAENATS

Function

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity)

Protein Sequence

10 MSGEDEQQEQ 20 TIAEDLVVTK 30 YKMGGDIANR 40 VLRSLVEASS 50 SGVSVLSLCE 60 KGDAMIMEET 70 GKIFKKEKEM 80 KKGIAFPTSI 90 SVNNCVCHFS 100 PLKSDQDYIL 110 KEGDLVKIDL 120 GVHVDGFIAN 130 VAHTFVVDVA 140 QGTQVTGRKA 150 DVIKAAHLCA 160 EAALRLVKPG 170 NQNTQVTEAW 180 NKVAHSFNCT 190 PIEGMLSHQL 200 KQHVIDGEKT 210 IIQNPTDQQK 220 KDHEKAEFEV 230 HEVYAVDVLV 240 SSGEGKAKDA 250 GQRTTIYKRD 260 PSKQYGLKMK 270 TSRAFFSEVE 280 RRFDAMPFTL 290 RAFEDEKKAR 300 MGVVECAKHE 310 LLQPFNVLYE 320 KEGEFVAQFK 330 FTVLLMPNGP 340 MRITSGPFEP 350 DLYKSEMEVQ 360 DAELKALLQS 370 SASRKTQKKK 380 KKKASKTAEN 390 ATSGETLEEN EAGD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003676 nucleic acid binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0006417 regulation of translation
Biological Process GO:0006364 rRNA processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.