Search Results
Overview
| Uniprot ID | Q9UQB8 |
|---|---|
| Protein Name | BAR/IMD domain-containing adapter protein 2 |
| Gene Name | BAIAP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 350 | VRKSVTPKNSYATTE |
Function
Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth, neuronal differentiation and neuronal migration (PubMed:41133935). Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (PubMed:41133935)
Protein Sequence
10
MSLSRSEEMH
20
RLTENVYKTI
30
MEQFNPSLRN
40
FIAMGKNYEK
50
ALAGVTYAAK
60
GYFDALVKMG
70
ELASESQGSK
80
ELGDVLFQMA
90
EVHRQIQNQL
100
EEMLKSFHNE
110
LLTQLEQKVE
120
LDSRYLSAAL
130
KKYQTEQRSK
140
GDALDKCQAE
150
LKKLRKKSQG
160
SKNPQKYSDK
170
ELQYIDAISN
180
KQGELENYVS
190
DGYKTALTEE
200
RRRFCFLVEK
210
QCAVAKNSAA
220
YHSKGKELLA
230
QKLPLWQQAC
240
ADPSKIPERA
250
VQLMQQVASN
260
GATLPSALSA
270
SKSNLVISDP
280
IPGAKPLPVP
290
PELAPFVGRM
300
SAQESTPIMN
310
GVTGPDGEDY
320
SPWADRKAAQ
330
PKSLSPPQSQ
340
SKLSDSYSNT
350
LPVRKSVTPK
360
NSYATTENKT
370
LPRSSSMAAG
380
LERNGRMRVK
390
AIFSHAAGDN
400
STLLSFKEGD
410
LITLLVPEAR
420
DGWHYGESEK
430
TKMRGWFPFS
440
YTRVLDSDGS
450
DRLHMSLQQG
460
KSSSTGNLLD
470
KDDLAIPPPD
480
YGAASRAFPA
490
QTASGFKQRP
500
YSVAVPAFSQ
510
GLDDYGARSM
520
SRNPFAHVQL
530
KPTVTNDRCD
540
LSAQGPEGRE
550
HGDGSARTLA
GR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0061846 | dendritic spine cytoplasm |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0061845 | neuron projection branch point |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| Molecular Function | GO:0008093 | cytoskeletal anchor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0070064 | proline-rich region binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Biological Process | GO:0051764 | actin crosslink formation |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:1905232 | cellular response to L-glutamate |
| Biological Process | GO:0046847 | filopodium assembly |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0007009 | plasma membrane organization |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| Biological Process | GO:0035418 | protein localization to synapse |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.