Search Results
Overview
| Uniprot ID | Q9UQL6 |
|---|---|
| Protein Name | Histone deacetylase 5 |
| Gene Name | HDAC5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 537 | QLGKILTKTGELPRQ |
| 821 | KVAAGELKNGFAIIR |
Function
In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758)
Protein Sequence
10
MNSPNESDGM
20
SGREPSLEIL
30
PRTSLHSIPV
40
TVEVKPVLPR
50
AMPSSMGGGG
60
GGSPSPVELR
70
GALVGSVDPT
80
LREQQLQQEL
90
LALKQQQQLQ
100
KQLLFAEFQK
110
QHDHLTRQHE
120
VQLQKHLKQQ
130
QEMLAAKQQQ
140
EMLAAKRQQE
150
LEQQRQREQQ
160
RQEELEKQRL
170
EQQLLILRNK
180
EKSKESAIAS
190
TEVKLRLQEF
200
LLSKSKEPTP
210
GGLNHSLPQH
220
PKCWGAHHAS
230
LDQSSPPQSG
240
PPGTPPSYKL
250
PLPGPYDSRD
260
DFPLRKTASE
270
PNLKVRSRLK
280
QKVAERRSSP
290
LLRRKDGTVI
300
STFKKRAVEI
310
TGAGPGASSV
320
CNSAPGSGPS
330
SPNSSHSTIA
340
ENGFTGSVPN
350
IPTEMLPQHR
360
ALPLDSSPNQ
370
FSLYTSPSLP
380
NISLGLQATV
390
TVTNSHLTAS
400
PKLSTQQEAE
410
RQALQSLRQG
420
GTLTGKFMST
430
SSIPGCLLGV
440
ALEGDGSPHG
450
HASLLQHVLL
460
LEQARQQSTL
470
IAVPLHGQSP
480
LVTGERVATS
490
MRTVGKLPRH
500
RPLSRTQSSP
510
LPQSPQALQQ
520
LVMQQQHQQF
530
LEKQKQQQLQ
540
LGKILTKTGE
550
LPRQPTTHPE
560
ETEEELTEQQ
570
EVLLGEGALT
580
MPREGSTESE
590
STQEDLEEED
600
EEDDGEEEED
610
CIQVKDEEGE
620
SGAEEGPDLE
630
EPGAGYKKLF
640
SDAQPLQPLQ
650
VYQAPLSLAT
660
VPHQALGRTQ
670
SSPAAPGGMK
680
SPPDQPVKHL
690
FTTGVVYDTF
700
MLKHQCMCGN
710
THVHPEHAGR
720
IQSIWSRLQE
730
TGLLSKCERI
740
RGRKATLDEI
750
QTVHSEYHTL
760
LYGTSPLNRQ
770
KLDSKKLLGP
780
ISQKMYAVLP
790
CGGIGVDSDT
800
VWNEMHSSSA
810
VRMAVGCLLE
820
LAFKVAAGEL
830
KNGFAIIRPP
840
GHHAEESTAM
850
GFCFFNSVAI
860
TAKLLQQKLN
870
VGKVLIVDWD
880
IHHGNGTQQA
890
FYNDPSVLYI
900
SLHRYDNGNF
910
FPGSGAPEEV
920
GGGPGVGYNV
930
NVAWTGGVDP
940
PIGDVEYLTA
950
FRTVVMPIAH
960
EFSPDVVLVS
970
AGFDAVEGHL
980
SPLGGYSVTA
990
RCFGHLTRQL
1000
MTLAGGRVVL
1010
ALEGGHDLTA
1020
ICDASEACVS
1030
ALLSVELQPL
1040
DEAVLQQKPN
1050
INAVATLEKV
1060
IEIQSKHWSC
1070
VQKFAAGLGR
1080
SLREAQAGET
1090
EEAETVSAMA
1100
LLSVGAEQAQ
1110
AAAAREHSPR
1120
PAEEPMEQEP
AL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001216 | DNA-binding transcription activator activity |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0141221 | histone deacetylase activity, hydrolytic mechanism |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0033558 | protein lysine deacetylase activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Biological Process | GO:0042113 | B cell activation |
| Biological Process | GO:0030183 | B cell differentiation |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045814 | negative regulation of gene expression, epigenetic |
| Biological Process | GO:0010832 | negative regulation of myotube differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010830 | regulation of myotube differentiation |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.