Overview
| Uniprot ID | Q9UQM7 |
|---|
| Protein Name | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
|---|
| Gene Name | CAMK2A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 146 |
ENLLLASKLKGAAVK |
| 250 |
EAKDLINKMLTINPS |
| 258 |
MLTINPSKRITAAEA |
| 267 |
ITAAEALKHPWISHR |
| 292 |
ETVDCLKKFNARRKL |
| 317 |
TRNFSGGKSGGNKKS |
| 42 |
AGQEYAAKIINTKKL |
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (PubMed:40281343). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)
Protein Sequence
10
MATITCTRFT
20
EEYQLFEELG
30
KGAFSVVRRC
40
VKVLAGQEYA
50
AKIINTKKLS
60
ARDHQKLERE
70
ARICRLLKHP
80
NIVRLHDSIS
90
EEGHHYLIFD
100
LVTGGELFED
110
IVAREYYSEA
120
DASHCIQQIL
130
EAVLHCHQMG
140
VVHRDLKPEN
150
LLLASKLKGA
160
AVKLADFGLA
170
IEVEGEQQAW
180
FGFAGTPGYL
190
SPEVLRKDPY
200
GKPVDLWACG
210
VILYILLVGY
220
PPFWDEDQHR
230
LYQQIKAGAY
240
DFPSPEWDTV
250
TPEAKDLINK
260
MLTINPSKRI
270
TAAEALKHPW
280
ISHRSTVASC
290
MHRQETVDCL
300
KKFNARRKLK
310
GAILTTMLAT
320
RNFSGGKSGG
330
NKKSDGVKES
340
SESTNTTIED
350
EDTKVRKQEI
360
IKVTEQLIEA
370
ISNGDFESYT
380
KMCDPGMTAF
390
EPEALGNLVE
400
GLDFHRFYFE
410
NLWSRNSKPV
420
HTTILNPHIH
430
LMGDESACIA
440
YIRITQYLDA
450
GGIPRTAQSE
460
ETRVWHRRDG
470
KWQIVHFHRS
GAPSVLPH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005954 |
calcium- and calmodulin-dependent protein kinase complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0030666 |
endocytic vesicle membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004683 |
calcium/calmodulin-dependent protein kinase activity |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0035254 |
glutamate receptor binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0038166 |
angiotensin-activated signaling pathway |
| Biological Process |
GO:0006816 |
calcium ion transport |
| Biological Process |
GO:0035458 |
cellular response to interferon-beta |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:0060996 |
dendritic spine development |
| Biological Process |
GO:0000082 |
G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0060291 |
long-term synaptic potentiation |
| Biological Process |
GO:0110076 |
negative regulation of ferroptosis |
| Biological Process |
GO:0051928 |
positive regulation of calcium ion transport |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0010666 |
positive regulation of cardiac muscle cell apoptotic process |
| Biological Process |
GO:0046427 |
positive regulation of receptor signaling pathway via JAK-STAT |
| Biological Process |
GO:2000124 |
regulation of endocannabinoid signaling pathway |
| Biological Process |
GO:1902108 |
regulation of mitochondrial membrane permeability involved in apoptotic process |
| Biological Process |
GO:2001222 |
regulation of neuron migration |
| Biological Process |
GO:0048168 |
regulation of neuronal synaptic plasticity |
| Biological Process |
GO:0046928 |
regulation of neurotransmitter secretion |
| Biological Process |
GO:1903076 |
regulation of protein localization to plasma membrane |
| Biological Process |
GO:0002931 |
response to ischemia |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.