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Overview

Uniprot IDQ9UQR0
Protein NameSex comb on midleg-like protein 2
Gene NameSCML2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
302 PKRSSSVKNITPRKK
343 RDRGMLYKDVASGPC
599 KSSPHEVKFQMQRKS
605 VKFQMQRKSEAPSYI

Function

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)

Protein Sequence

10 MGQTVNEDSM 20 DVKKENQEKT 30 PQSSTSSVQR 40 DDFHWEEYLK 50 ETGSISAPSE 60 CFRQSQIPPV 70 NDFKVGMKLE 80 ARDPRNATSV 90 CIATVIGITG 100 ARLRLRLDGS 110 DNRNDFWRLV 120 DSPDIQPVGT 130 CEKEGDLLQP 140 PLGYQMNTSS 150 WPMFLLKTLN 160 GSEMASATLF 170 KKEPPKPPLN 180 NFKVGMKLEA 190 IDKKNPYLIC 200 PATIGDVKGD 210 EVHITFDGWS 220 GAFDYWCKYD 230 SRDIFPAGWC 240 RLTGDVLQPP 250 GTSVPIVKNI 260 AKTESSPSEA 270 SQHSMQSPQK 280 TTLILPTQQV 290 RRSSRIKPPG 300 PTAVPKRSSS 310 VKNITPRKKG 320 PNSGKKEKPL 330 PVICSTSAAS 340 LKSLTRDRGM 350 LYKDVASGPC 360 KIVMSTVCVY 370 VNKHGNFGPH 380 LDPKRIQQLP 390 DHFGPGPVNV 400 VLRRIVQACV 410 DCALETKTVF 420 GYLKPDNRGG 430 EVITASFDGE 440 THSIQLPPVN 450 SASFALRFLE 460 NFCHSLQCDN 470 LLSSQPFSSS 480 RGHTHSSAEH 490 DKNQSAKEDV 500 TERQSTKRSP 510 QQTVPYVVPL 520 SPKLPKTKEY 530 ASEGEPLFAG 540 GSAIPKEENL 550 SEDSKSSSLN 560 SGNYLNPACR 570 NPMYIHTSVS 580 QDFSRSVPGT 590 TSSPLVGDIS 600 PKSSPHEVKF 610 QMQRKSEAPS 620 YIAVPDPSVL 630 KQGFSKDPST 640 WSVDEVIQFM 650 KHTDPQISGP 660 LADLFRQHEI 670 DGKALFLLKS 680 DVMMKYMGLK 690 LGPALKLCYY 700 IEKLKEGKYS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031519 PcG protein complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.