Search Results

Overview

Uniprot IDQ9UQR1
Protein NameZinc finger protein 148
Gene NameZNF148
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
142 REPVDLQKKKKRKQR
143 EPVDLQKKKKRKQRS
153 RKQRSPAKILTINED
291 KLNRCAIKGGLLTSE
314 PKDNSLPKKKRQKTE
323 KRQKTEKKSSGMDKE
335 DKESALDKSDLKKDK
342 KSDLKKDKNDYLPLY
389 SGEIHPPKLVLKKIN
424 YEESKVSKYAFELVD
472 DDAMQFLKKKRYLQA

Function

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

Protein Sequence

10 MNIDDKLEGL 20 FLKCGGIDEM 30 QSSRTMVVMG 40 GVSGQSTVSG 50 ELQDSVLQDR 60 SMPHQEILAA 70 DEVLQESEMR 80 QQDMISHDEL 90 MVHEETVKND 100 EEQMETHERL 110 PQGLQYALNV 120 PISVKQEITF 130 TDVSEQLMRD 140 KKQIREPVDL 150 QKKKKRKQRS 160 PAKILTINED 170 GSLGLKTPKS 180 HVCEHCNAAF 190 RTNYHLQRHV 200 FIHTGEKPFQ 210 CSQCDMRFIQ 220 KYLLQRHEKI 230 HTGEKPFRCD 240 ECGMRFIQKY 250 HMERHKRTHS 260 GEKPYQCEYC 270 LQYFSRTDRV 280 LKHKRMCHEN 290 HDKKLNRCAI 300 KGGLLTSEED 310 SGFSTSPKDN 320 SLPKKKRQKT 330 EKKSSGMDKE 340 SALDKSDLKK 350 DKNDYLPLYS 360 SSTKVKDEYM 370 VAEYAVEMPH 380 SSVGGSHLED 390 ASGEIHPPKL 400 VLKKINSKRS 410 LKQPLEQNQT 420 ISPLSTYEES 430 KVSKYAFELV 440 DKQALLDSEG 450 NADIDQVDNL 460 QEGPSKPVHS 470 STNYDDAMQF 480 LKKKRYLQAA 490 SNNSREYALN 500 VGTIASQPSV 510 TQAAVASVID 520 ESTTASILES 530 QALNVEIKSN 540 HDKNVIPDEV 550 LQTLLDHYSH 560 KANGQHEISF 570 SVADTEVTSS 580 ISINSSEVPE 590 VTPSENVGSS 600 SQASSSDKAN 610 MLQEYSKFLQ 620 QALDRTSQND 630 AYLNSPSLNF 640 VTDNQTLPNQ 650 PAFSSIDKQV 660 YATMPINSFR 670 SGMNSPLRTT 680 PDKSHFGLIV 690 GDSQHSFPFS 700 GDETNHASAT 710 STQDFLDQVT 720 SQKKAEAQPV 730 HQAYQMSSFE 740 QPFRAPYHGS 750 RAGIATQFST 760 ANGQVNLRGP 770 GTSAEFSEFP 780 LVNVNDNRAG 790 MTSSPDATTG QTFG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006968 cellular defense response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0021762 substantia nigra development

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.