Search Results
Overview
| Uniprot ID | Q9WTP6 |
|---|---|
| Protein Name | Adenylate kinase 2, mitochondrial |
| Gene Name | Ak2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 62 | ASGSELGKKLKATMD |
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis
Protein Sequence
10
MAPNVLASEP
20
EIPKGIRAVL
30
LGPPGAGKGT
40
QAPKLAENFC
50
VCHLATGDML
60
RAMVASGSEL
70
GKKLKATMDA
80
GKLVSDEMVV
90
ELIEKNLETP
100
SCKNGFLLDG
110
FPRTVRQAEM
120
LDDLMEKRKE
130
KLDSVIEFSI
140
QDSLLIRRIT
150
GRLIHPKSGR
160
SYHEEFNPPK
170
EPMKDDITGE
180
PLIRRSDDNE
190
KALKTRLEAY
200
HTQTTPLVEY
210
YRKRGIHCAI
220
DASQTPDIVF
230
ASILAAFSKA
TCKDLVMFI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097226 | sperm mitochondrial sheath |
| Molecular Function | GO:0004017 | AMP kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0046034 | ATP metabolic process |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.