Search Results
Overview
| Uniprot ID | Q9WTP7 |
|---|---|
| Protein Name | GTP:AMP phosphotransferase AK3, mitochondrial |
| Gene Name | Ak3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 165 | LIQREDDKPETVIKR |
| 171 | DKPETVIKRLKAYEA |
| 20 | MGAPGSGKGTVSSRI |
| 29 | TVSSRITKHFELKHL |
| 34 | ITKHFELKHLSSGDL |
| 64 | KTFIDQGKLIPDDVM |
Function
Mitochondrial adenylate kinase with a specific GTP:AMP phosphotransferase activity. Could also use ITP as phosphate donor. Its physiological function is to recycle GTP into GDP which is necessary for the TCA cycle in the mitochondrial matrix
Protein Sequence
10
MGASGRLLRA
20
VIMGAPGSGK
30
GTVSSRITKH
40
FELKHLSSGD
50
LLRQNMLQGT
60
EIGVLAKTFI
70
DQGKLIPDDV
80
MTRLALHELK
90
TLTQCSWLLD
100
GFPRTLPQAE
110
ALDKVYQIDT
120
VINLNVPFEV
130
IKQRLTARWI
140
HPASGRVYNI
150
EFNPPKTVGI
160
DDLTGEPLIQ
170
REDDKPETVI
180
KRLKAYEAQT
190
EPVLQYYQKK
200
GVLETFSGTE
210
TNKIWPHVYS
220
FLQTKVPETT
QKASVTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004017 | AMP kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046899 | nucleoside triphosphate adenylate kinase activity |
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0006756 | AMP phosphorylation |
| Biological Process | GO:0046060 | dATP metabolic process |
| Biological Process | GO:0046039 | GTP metabolic process |
| Biological Process | GO:0046041 | ITP metabolic process |
| Biological Process | GO:0009142 | nucleoside triphosphate biosynthetic process |
| Biological Process | GO:0046051 | UTP metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.