Search Results

Overview

Uniprot IDQ9WUB3
Protein NameGlycogen phosphorylase, muscle form
Gene NamePygm
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
10 RPLSDQDKRKQISVR
29 VENVSELKKNFNRHL
290 NDNFFEGKELRLKQE
438 LVEEGAVKRINMAHL
465 RIHSEILKKTIFKDF
78 TQQHYYEKDPKRIYY
811 RNIATSGKFSSDRTI

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MSRPLSDQDK 20 RKQISVRGLA 30 GVENVSELKK 40 NFNRHLHFTL 50 VKDRNVATPR 60 DYYFALAHTV 70 RDHLVGRWIR 80 TQQHYYEKDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLALENACD 120 EATYQLGLDM 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEFGIFNQK 180 ICGGWQMEEA 190 DDWLRYGNPW 200 EKARPEFTLP 210 VHFYGRVEHT 220 SQGAKWVDTQ 230 VVLAMPYDTP 240 VPGYRNNVVN 250 TMRLWSAKAP 260 NDFNLKDFNV 270 GGYIQAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDIIR 320 RFKSSKFGSR 330 DPVRTNFDAF 340 PDKVAIQLND 350 THPSLAIPEL 360 MRILVDLERL 370 DWDKAWDVTV 380 KTCAYTNHTV 390 LPEALERWPV 400 HLMETLLPRH 410 LQIIYEINQR 420 FLNRVAAAFP 430 GDVDRLRRMS 440 LVEEGAVKRI 450 NMAHLCIAGS 460 HAVNGVARIH 470 SEILKKTIFK 480 DFYELEPHKF 490 QNKTNGITPR 500 RWLVLCNPGL 510 AEVIAERIGE 520 DYISDLDQLR 530 KLLSYVDDEA 540 FIRDVAKVKQ 550 ENKLKFSAYL 560 EREYKVHINP 570 NSLFDVQVKR 580 IHEYKRQLLN 590 CLHIITLYNR 600 IKREPNRFMV 610 PRTIMIGGKA 620 APGYHMAKMI 630 IKLITAIGDV 640 VNHDPAVGDR 650 LRVIFLENYR 660 VSLAEKVIPA 670 ADLSEQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENFF 720 IFGMRVEDVE 730 RLDQRGYNAQ 740 EYYDRIPELR 750 QIIEQLSSGF 760 FSPKQPDLFK 770 DIVNMLMHHD 780 RFKVFADYEE 790 YIKCQDKVSE 800 LYKNPREWTR 810 MVIRNIATSG 820 KFSSDRTIAQ 830 YAREIWGVEP 840 SRQRLPAPDE KI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0030018 Z disc
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0051591 response to cAMP
Biological Process GO:0001666 response to hypoxia

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.