Overview
| Uniprot ID | Q9WUL7 |
|---|
| Protein Name | ADP-ribosylation factor-like protein 3 |
|---|
| Gene Name | Arl3 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
LSILRKLKSAPDQEV |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:18376416). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms (PubMed:15979089). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (PubMed:25405894)
Protein Sequence
10
MGLLSILRKL
20
KSAPDQEVRI
30
LLLGLDNAGK
40
TTLLKQLASE
50
DISHITPTQG
60
FNIKSVQSQG
70
FKLNVWDIGG
80
QRKIRPYWRS
90
YFENTDILIY
100
VIDSADRKRF
110
EETGQELTEL
120
LEEEKLSCVP
130
VLIFANKQDL
140
LTAAPASEIA
150
EGLNLHTIRD
160
RVWQIQSCSA
170
LTGEGVQDGM
180
NWVCKNVNAK
KK
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0015031 |
protein transport |
| Cellular Component |
GO:0005930 |
axoneme |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0035869 |
ciliary transition zone |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005881 |
cytoplasmic microtubule |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032391 |
photoreceptor connecting cilium |
| Cellular Component |
GO:0005876 |
spindle microtubule |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0006893 |
Golgi to plasma membrane transport |
| Biological Process |
GO:0042073 |
intraciliary transport |
| Biological Process |
GO:0001822 |
kidney development |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
| Biological Process |
GO:0042461 |
photoreceptor cell development |
| Biological Process |
GO:0006892 |
post-Golgi vesicle-mediated transport |
| Biological Process |
GO:1903441 |
protein localization to ciliary membrane |
| Biological Process |
GO:0061512 |
protein localization to cilium |
| Biological Process |
GO:0007264 |
small GTPase-mediated signal transduction |
| Biological Process |
GO:0007224 |
smoothened signaling pathway |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.