Search Results

Overview

Uniprot IDQ9WUM5
Protein NameSuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Gene NameSuclg1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
105 LPVFNTVKEAKEKTG
192 IMPGHIHKKGRIGIV
308 GAIIAGGKGGAKEKI
48 GSYTASRKHIYIDKN
54 RKHIYIDKNTKIICQ
57 IYIDKNTKIICQGFT
66 ICQGFTGKQGTFHSQ
81 QALEYGTKLVGGTTP
90 VGGTTPGKGGQKHLG
94 TPGKGGQKHLGLPVF

Function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase

Protein Sequence

10 MTATVVAAAA 20 TATMVSSSSG 30 LAAARLLSRT 40 FLLQQNGIRH 50 GSYTASRKHI 60 YIDKNTKIIC 70 QGFTGKQGTF 80 HSQQALEYGT 90 KLVGGTTPGK 100 GGQKHLGLPV 110 FNTVKEAKEK 120 TGATASVIYV 130 PPPFAAAAIN 140 EAIDAEIPLV 150 VCITEGIPQQ 160 DMVRVKHRLT 170 RQGTTRLIGP 180 NCPGVINPGE 190 CKIGIMPGHI 200 HKKGRIGIVS 210 RSGTLTYEAV 220 HQTTQVGLGQ 230 SLCIGIGGDP 240 FNGTDFIDCL 250 EVFLNDPATE 260 GIILIGEIGG 270 HAEENAAAFL 280 KEHNSGPKAK 290 PVVSFIAGIT 300 APPGRRMGHA 310 GAIIAGGKGG 320 AKEKISALQS 330 AGVVVSMSPA 340 QLGTTIYKEF EKRKML

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0009361 succinate-CoA ligase complex (ADP-forming)
Cellular Component GO:0045244 succinate-CoA ligase complex (GDP-forming)
Molecular Function GO:0019003 GDP binding
Molecular Function GO:0050074 malate-CoA ligase activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0004775 succinate-CoA ligase (ADP-forming) activity
Molecular Function GO:0004776 succinate-CoA ligase (GDP-forming) activity
Biological Process GO:0006108 malate metabolic process
Biological Process GO:0006105 succinate metabolic process
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0110052 toxic metabolite repair
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.