Search Results
Overview
| Uniprot ID | Q9WUR2 |
|---|---|
| Protein Name | Enoyl-CoA delta isomerase 2 |
| Gene Name | Eci2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | DEKARESKDILVTSE |
| 158 | ITFNRPTKKNAISFQ |
| 159 | TFNRPTKKNAISFQM |
| 53 | NQVKLLKKDPGNEVK |
| 60 | KDPGNEVKLRLYALY |
| 88 | GMLDFVNKAKWDAWN |
| 90 | LDFVNKAKWDAWNAL |
Function
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (PubMed:24344334). Has a preference for 3-trans substrates (By similarity)
Protein Sequence
10
MAAVTWSRAR
20
CWCPSVLQVF
30
RLQVAKLHLG
40
RPTMRASQQD
50
FENALNQVKL
60
LKKDPGNEVK
70
LRLYALYKQA
80
TEGPCNMPKP
90
GMLDFVNKAK
100
WDAWNALGSL
110
PKETARQNYV
120
DLVSSLSSSS
130
EAPSQGKRGA
140
DEKARESKDI
150
LVTSEDGITK
160
ITFNRPTKKN
170
AISFQMYRDI
180
ILALKNASTD
190
NTVMAVFTGT
200
GDYYCSGNDL
210
TNFTSATGGI
220
EEAASNGAVL
230
LRDFVNSFID
240
FPKPLVAVVN
250
GPAVGISVTL
260
LGLFDAVFAS
270
DRATFHTPFS
280
QLGQSPEACS
290
SYTFPKMMGS
300
AKAAEMLLFG
310
KKLTAREAWA
320
QGLVTEVFPE
330
STFETEVWTR
340
LKTYAKLPPN
350
AMRISKELIR
360
KNEKEKLYAV
370
NAEECTTLQA
380
RWLSEECMNA
390
IMSFVSRKPK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004165 | delta(3)-delta(2)-enoyl-CoA isomerase activity |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
| Biological Process | GO:0009062 | fatty acid catabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.