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Overview

Uniprot ID	Q9WVL0
Protein Name	Maleylacetoacetate isomerase
Gene Name	Gstz1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
177	VANAERFKVDLSPYP

Function

Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity)

Protein Sequence

10 MQAGKPILYS 20 YFRSSCSWRV 30 RIALALKGID 40 YEIVPINLIK 50 DGGQQFTEEF 60 QTLNPMKQVP 70 ALKIDGITIV 80 QSLAIMEYLE 90 ETRPIPRLLP 100 QDPQKRAIVR 110 MISDLIASGI 120 QPLQNLSVLK 130 QVGQENQMQW 140 AQKVITSGFN 150 ALEKILQSTA 160 GKYCVGDEVS 170 MADVCLVPQV 180 ANAERFKVDL 190 SPYPTISHIN 200 KELLALEVFQ 210 VSHPRRQPDT PAELRT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004364	glutathione transferase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0016034	maleylacetoacetate isomerase activity
Molecular Function	GO:0042803	protein homodimerization activity
Biological Process	GO:1990748	cellular detoxification
Biological Process	GO:0006749	glutathione metabolic process
Biological Process	GO:0006559	L-phenylalanine catabolic process
Biological Process	GO:0006572	L-tyrosine catabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.