Search Results
Overview
| Uniprot ID | Q9XT90 |
|---|---|
| Protein Name | Matrix metalloproteinase-14 |
| Gene Name | MMP14 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 384 | FVFFKGDKHWVFDEA |
| 449 | AVDSEYPKNIKVWEG |
| 452 | SEYPKNIKVWEGIPE |
| 483 | YKGNKYWKFNNQKLK |
| 488 | YWKFNNQKLKVEPGY |
| 490 | KFNNQKLKVEPGYPK |
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis
Protein Sequence
10
MSPAPRPVRS
20
LLLPLLTLAS
30
ALASLSSAQS
40
FSPEAWLQQY
50
GYLPPGDLRT
60
HTQRSPQSLS
70
AAIAAMQRFY
80
GLRVTGKADA
90
DTMKAMRRPR
100
CGVPDKFGAE
110
IKANVRRKRY
120
AIQGLKWQHN
130
EITFCIQNYT
140
PKVGEYATFE
150
AIRKAFRVWE
160
SATPLRFREV
170
PYAYIREGHE
180
KQADIMIFFA
190
EGFHGDSTPF
200
DGEGGFLAHA
210
YFPGPNIGGD
220
THFDSAEPWT
230
VRNEDLNGND
240
IFLVAVHELG
250
HALGLEHSND
260
PSAIMAPFYQ
270
WMDTENFVLP
280
DDDRRGIQQL
290
YGSESGFPTK
300
MPPQPRTTSK
310
PSVPDKPKNP
320
TYGPNICDGN
330
FDTVAMLRGE
340
MFVFKERWFW
350
RVRKNQVMDG
360
YPMPIGQFWR
370
GLPASINTAY
380
ERKDGKFVFF
390
KGDKHWVFDE
400
ASLEPGYPKH
410
IKELGRRLPT
420
DKIDAALFWM
430
PNGKDYFFRG
440
NKYYRFNEEL
450
RAVDSEYPKN
460
IKVWEGIPES
470
PRGSFMGSDE
480
VFTYFYKGNK
490
YWKFNNQKLK
500
VEPGYPKSAL
510
RDWMGCPSGG
520
RPDEGTEEET
530
EVIIIEVDEE
540
GSGAVSAAAV
550
VLPVLLLLLV
560
LAVGLAVFFF
570
RRHGTPKRLL
580
YCQRSLLDKV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0048754 | branching morphogenesis of an epithelial tube |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0030574 | collagen catabolic process |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0045746 | negative regulation of Notch signaling pathway |
| Biological Process | GO:0045579 | positive regulation of B cell differentiation |
| Biological Process | GO:0010831 | positive regulation of myotube differentiation |
| Biological Process | GO:0001501 | skeletal system development |
| Biological Process | GO:0031638 | zymogen activation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.