Search Results
Overview
| Uniprot ID | Q9Y237 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 |
| Gene Name | PIN4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | SGSGKAGKGGAASGS |
| 27 | GSDSADKKAQGPKGG |
| 32 | DKKAQGPKGGGNAVK |
Function
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA
Protein Sequence
10
MPPKGKSGSG
20
KAGKGGAASG
30
SDSADKKAQG
40
PKGGGNAVKV
50
RHILCEKHGK
60
IMEAMEKLKS
70
GMRFNEVAAQ
80
YSEDKARQGG
90
DLGWMTRGSM
100
VGPFQEAAFA
110
LPVSGMDKPV
120
FTDPPVKTKF
130
GYHIIMVEGR
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030684 | preribosome |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0003681 | bent DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006364 | rRNA processing |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.