Search Results

Overview

Uniprot IDQ9Y266
Protein NameNuclear migration protein nudC
Gene NameNUDC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 ETSGPQIKELTDEEA
122 LQLEIDQKKDAENHE
123 QLEIDQKKDAENHEA
196 VNFRLKGKDMVVDIQ
247 VVTVHLEKINKMEWW
267 SDPEINTKKINPENS
268 DPEINTKKINPENSK
275 KINPENSKLSDLDSE
297 MMYDQRQKSMGLPTS
315 KKQEILKKFMDQHPE
327 HPEMDFSKAKFN***
39 FFSFLRRKTDFFIGG
68 HHNQLAQKTRREKRA
96 ARLAKEAKSETSGPQ

Function

Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857)

Protein Sequence

10 MGGEQEEERF 20 DGMLLAMAQQ 30 HEGGVQELVN 40 TFFSFLRRKT 50 DFFIGGEEGM 60 AEKLITQTFS 70 HHNQLAQKTR 80 REKRARQEAE 90 RREKAERAAR 100 LAKEAKSETS 110 GPQIKELTDE 120 EAERLQLEID 130 QKKDAENHEA 140 QLKNGSLDSP 150 GKQDTEEDEE 160 EDEKDKGKLK 170 PNLGNGADLP 180 NYRWTQTLSE 190 LDLAVPFCVN 200 FRLKGKDMVV 210 DIQRRHLRVG 220 LKGQPAIIDG 230 ELYNEVKVEE 240 SSWLIEDGKV 250 VTVHLEKINK 260 MEWWSRLVSS 270 DPEINTKKIN 280 PENSKLSDLD 290 SETRSMVEKM 300 MYDQRQKSMG 310 LPTSDEQKKQ 320 EILKKFMDQH 330 PEMDFSKAKF N

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005874 microtubule
Cellular Component GO:0030496 midbody
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005819 spindle
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0051301 cell division
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0007097 nuclear migration
Biological Process GO:0006457 protein folding
Biological Process GO:0043434 response to peptide hormone

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.